Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | EDNRA | P25101 | 3/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | CCKBR | P32239 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8282034 | 0.79 | MAPT (0.43) | MAPTEDNRAPPARGPPARDPPARA | |
| SCHEMBL13622649 | 0.79 | MAPT (0.43) | MAPTEDNRAPPARGPPARDPPARA | |
| SCHEMBL29164906 | 0.78 | EDNRA (0.51) | MAPTEDNRAPPARGPPARDPPARA | |
| SCHEMBL12600998 | 0.77 | CA9 (0.55) | MAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL8290354 | 0.75 | GBA1 (0.33) | — | |
| SCHEMBL11469582 | 0.75 | EDNRA (0.56) | MAPTEDNRAPPARGPPARDPPARA | |
| SCHEMBL7090863 | 0.75 | PPARG (0.49) | MAPTEDNRAPPARGPPARDPPARA | |
| SCHEMBL11117907 | 0.74 | EDNRA (0.53) | MAPTEDNRAPPARGPPARDPPARA | |
| SCHEMBL12293606 | 0.74 | MAPT (0.67) | MAPTEDNRAPPARGPPARDPPARA | |
| SCHEMBL22827920 | 0.74 | EDNRA (0.56) | MAPTEDNRAPPARGPPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730142-B1 | NOVEL KETOAMIDES WITH CYCLIC P4'S AS INHIBITORS OF NS3 SERINE PROTEASE OF HEPATITIS C VIRUS | SCHERING CORP (US) | 2011-06-29 | — | — | EP | disclosed |