Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.53 |
| ▸ | IGF1R | P08069 | 2/20 | 0.49 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 3/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | CDK7 | P50613 | 2/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 5/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12606292 | 0.84 | SYK (0.61) | SYKIGF1RGSK3BJAK2CDK7 | |
| SCHEMBL12606282 | 0.82 | SYK (0.58) | SYKIGF1RGSK3BJAK2CDK7 | |
| SCHEMBL12606271 | 0.80 | SYK (0.66) | SYKIGF1RGSK3BJAK2CDK7 | |
| SCHEMBL12606259 | 0.78 | IGF1R (0.58) | SYKIGF1RGSK3BJAK2CDK7 | |
| SCHEMBL12606314 | 0.78 | SYK (0.53) | SYKIGF1RGSK3BJAK2CDK7 | |
| SCHEMBL1778605 | 0.77 | SYK (0.61) | SYKIGF1RGSK3BJAK2CDK7 | |
| SCHEMBL7168366 | 0.77 | IGF1R (0.61) | SYKIGF1RGSK3BJAK2CDK7 | |
| SCHEMBL1777884 | 0.76 | IGF1R (0.63) | SYKIGF1RGSK3BJAK2CDK7 | |
| SCHEMBL12606280 | 0.76 | SYK (0.51) | SYKIGF1RGSK3BJAK2CDK7 | |
| SCHEMBL12606327 | 0.76 | SYK (0.53) | SYKIGF1RGSK3BJAK2CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943616-B2 | Protein kinase inhibitors; astham; psoriasis; antiinflammatory agents; inflammatory bowel disorders | AVENTIS PHARMACEUTICALS INC. (US) | 2011-05-17 | — | — | US | disclosed |
| US-7943616-B2 | Protein kinase inhibitors; astham; psoriasis; antiinflammatory agents; inflammatory bowel disorders | AVENTIS PHARMACEUTICALS INC. (US) | 2011-05-17 | — | — | US | disclosed |
| EP-2233486-A1 | Azaindoles | Aventis Pharma Limited (GB) | 2010-09-29 | — | — | EP | disclosed |