Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.50 |
| ▸ | HTR2A | P28223 | 6/20 | 0.50 |
| ▸ | USP2 | O75604 | 5/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17751110 | 0.91 | CYP1A2 (0.50) | HTR1AHTR2AUSP2CYP1A2CYP3A4 | |
| SCHEMBL12696430 | 0.81 | AURKA (0.47) | HTR1AHTR2AUSP2CYP1A2CYP3A4 | |
| SCHEMBL30198174 | 0.80 | USP2 (0.44) | HTR1AHTR2AUSP2CYP1A2CYP3A4 | |
| SCHEMBL15473988 | 0.80 | USP2 (0.44) | HTR1AHTR2AUSP2CYP1A2CYP3A4 | |
| SCHEMBL3247475 | 0.76 | GALR2 (0.52) | HTR2AUSP2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9208512 | 0.76 | HTR2A (0.64) | HTR1AHTR2AADRA2AADRA2BADRA2C | |
| SCHEMBL17751105 | 0.73 | PAK4 (0.46) | HTR1AHTR2AUSP2CYP1A2CYP3A4 | |
| SCHEMBL12520958 | 0.72 | CYP1A2 (0.73) | HTR2AUSP2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5466283 | 0.71 | MTNR1A (0.69) | HTR1AHTR2ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8230070 | 0.70 | HTR2A (0.77) | HTR1AHTR2ACYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2688883-B1 | PYRIMIDINE DERIVATIVES | NOVIGA RES AB (SE) | 2016-05-18 | — | — | EP | disclosed |
| US-9006241-B2 | Pyrimidine derivatives | NOVIGA RESEARCH AB (SE) | 2015-04-14 | — | — | US | disclosed |
| US-9006241-B2 | Pyrimidine derivatives | NOVIGA RESEARCH AB (SE) | 2015-04-14 | — | — | US | disclosed |
| US-20140045845-A1 | NOVEL PYRIMIDINE DERIVATIVES | CHEMILIA AB (SE) | 2014-02-13 | — | — | US | disclosed |
| US-20140045845-A1 | NOVEL PYRIMIDINE DERIVATIVES | CHEMILIA AB (SE) | 2014-02-13 | — | — | US | disclosed |
| EP-2688883-A1 | NOVEL PYRIMIDINE DERIVATIVES | Chemilia AB (SE) | 2014-01-29 | — | — | EP | disclosed |
| WO-2012127032-A1 | NOVEL PYRIMIDINE DERIVATIVES | CHEMILIA AB (SE) | 2012-09-27 | — | — | WO | disclosed |
| WO-2012127032-A1 | NOVEL PYRIMIDINE DERIVATIVES | CHEMILIA AB (SE) | 2012-09-27 | — | — | WO | disclosed |
| EP-2502924-A1 | Novel pyrimidine derivatives | Chemilia AB (SE) | 2012-09-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140045845-A1 | NOVEL PYRIMIDINE DERIVATIVES | TYMS, DPYD, TYMP | HTR1A 1290/4885HTR2A 2953/4885USP2 4295/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.