Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICOSLG | O75144 | 3/20 | 0.43 |
| ▸ | ICOS | Q9Y6W8 | 3/20 | 0.43 |
| ▸ | CHUK | O15111 | 5/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12619474 | 0.90 | ICOSLG (0.44) | ICOSLGICOSCHUK | |
| SCHEMBL12619473 | 0.90 | ICOSLG (0.44) | ICOSLGICOSCHUK | |
| Mln-0415 SCHEMBL30489865 | 0.88 | ICOSLG (0.59) | ICOSLGICOSCHUK | |
| Mln-0415 SCHEMBL12619648 | 0.88 | ICOSLG (0.59) | ICOSLGICOSCHUK | |
| Mln-0415 SCHEMBL3805697 | 0.88 | ICOSLG (0.59) | ICOSLGICOSCHUK | |
| Mln-0415 SCHEMBL12619680 | 0.88 | ICOSLG (0.59) | ICOSLGICOSCHUK | |
| Mln-0415 SCHEMBL1798964 | 0.88 | ICOSLG (0.59) | ICOSLGICOSCHUK | |
| Mln-0415 SCHEMBL13270227 | 0.88 | ICOSLG (0.59) | ICOSLGICOSCHUK | |
| Mln-0415 SCHEMBL3805703 | 0.88 | ICOSLG (0.59) | ICOSLGICOSCHUK | |
| Mln-0415 SCHEMBL3809102 | 0.87 | ICOSLG (0.58) | ICOSLGICOSCHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951801-B2 | For therapy of inflammatory disease and cancer | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-05-31 | — | — | US | disclosed |
| US-7951801-B2 | For therapy of inflammatory disease and cancer | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-05-31 | — | — | US | disclosed |
| EP-2206713-A1 | Beta-carbolines useful for treating inflammatory disease | Millennium Pharmaceuticals, Inc. (US) | 2010-07-14 | — | — | EP | disclosed |