Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICOSLG | O75144 | 11/20 | 0.57 |
| ▸ | ICOS | Q9Y6W8 | 11/20 | 0.57 |
| ▸ | CHUK | O15111 | 12/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.42 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.35 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.34 |
| ▸ | FNTA | P49354 | 1/20 | 0.34 |
| ▸ | FNTB | P49356 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12619515 | 0.96 | ICOSLG (0.55) | ICOSLGICOSCHUKMEN1KMT2A | |
| SCHEMBL12619440 | 0.94 | ICOSLG (0.61) | ICOSLGICOSCHUKMEN1KMT2A | |
| SCHEMBL1801702 | 0.94 | ICOSLG (0.61) | ICOSLGICOSCHUKMEN1KMT2A | |
| SCHEMBL12619716 | 0.91 | ICOSLG (0.57) | ICOSLGICOSCHUKMEN1KMT2A | |
| SCHEMBL12619478 | 0.90 | ICOSLG (0.60) | ICOSLGICOSCHUKMEN1KMT2A | |
| SCHEMBL12619476 | 0.89 | ICOSLG (0.63) | ICOSLGICOSCHUKMEN1KMT2A | |
| SCHEMBL12653368 | 0.88 | ICOSLG (0.45) | ICOSLGICOSCHUKMEN1KMT2A | |
| SCHEMBL12619695 | 0.87 | ICOSLG (0.56) | ICOSLGICOSCHUKMEN1KMT2A | |
| SCHEMBL1800072 | 0.86 | ICOSLG (0.65) | ICOSLGICOSCHUKMEN1KMT2A | |
| SCHEMBL1800079 | 0.86 | ICOSLG (0.65) | ICOSLGICOSCHUKMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951801-B2 | For therapy of inflammatory disease and cancer | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-05-31 | — | — | US | disclosed |
| US-7951801-B2 | For therapy of inflammatory disease and cancer | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-05-31 | — | — | US | disclosed |
| EP-2206713-A1 | Beta-carbolines useful for treating inflammatory disease | Millennium Pharmaceuticals, Inc. (US) | 2010-07-14 | — | — | EP | disclosed |