Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICOSLG | O75144 | 10/20 | 0.45 |
| ▸ | ICOS | Q9Y6W8 | 10/20 | 0.45 |
| ▸ | CHUK | O15111 | 9/20 | 0.38 |
| ▸ | FNTA | P49354 | 1/20 | 0.34 |
| ▸ | FNTB | P49356 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.34 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.34 |
| ▸ | TSPO | P30536 | 2/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12619515 | 0.92 | ICOSLG (0.55) | ICOSLGICOSCHUKFNTAFNTB | |
| SCHEMBL12619802 | 0.88 | ICOSLG (0.57) | ICOSLGICOSCHUKFNTAFNTB | |
| SCHEMBL12619440 | 0.85 | ICOSLG (0.61) | ICOSLGICOSCHUKMEN1IKBKB | |
| SCHEMBL1801702 | 0.85 | ICOSLG (0.61) | ICOSLGICOSCHUKMEN1IKBKB | |
| SCHEMBL13349318 | 0.84 | ICOSLG (0.53) | ICOSLGICOSCHUKMEN1IKBKB | |
| SCHEMBL12619716 | 0.82 | ICOSLG (0.57) | ICOSLGICOSCHUKMEN1IKBKB | |
| SCHEMBL12653329 | 0.81 | ICOSLG (0.48) | ICOSLGICOSCHUKMEN1IKBKB | |
| SCHEMBL12653191 | 0.81 | ICOSLG (0.35) | ICOSLGICOS | |
| SCHEMBL12653424 | 0.80 | ICOSLG (0.49) | ICOSLGICOSCHUKMEN1IKBKB | |
| SCHEMBL12619478 | 0.80 | ICOSLG (0.60) | ICOSLGICOSCHUKMEN1IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951801-B2 | For therapy of inflammatory disease and cancer | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-05-31 | — | — | US | disclosed |