Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 18/20 | 0.70 |
| ▸ | KDR | P35968 | 4/20 | 0.70 |
| ▸ | KIT | P10721 | 10/20 | 0.68 |
| ▸ | ABL1 | P00519 | 10/20 | 0.68 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.68 |
| ▸ | LCK | P06239 | 4/20 | 0.68 |
| ▸ | LYN | P07948 | 4/20 | 0.68 |
| ▸ | FLT3 | P36888 | 4/20 | 0.68 |
| ▸ | DDR2 | Q16832 | 4/20 | 0.68 |
| ▸ | BCR | P11274 | 6/20 | 0.61 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.61 |
| ▸ | CA12 | O43570 | 1/20 | 0.61 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.61 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.61 |
| ▸ | STK10 | O94804 | 1/20 | 0.61 |
| ▸ | CA1 | P00915 | 1/20 | 0.61 |
| ▸ | CA2 | P00918 | 1/20 | 0.61 |
| ▸ | LDLR | P01130 | 1/20 | 0.61 |
| ▸ | RAF1 | P04049 | 1/20 | 0.61 |
| ▸ | FYN | P06241 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12627014 | 0.92 | KIT (0.68) | PDGFRAKDRKITABL1PDGFRB | |
| SCHEMBL11927818 | 0.90 | PDGFRA (0.72) | PDGFRAKDRKITABL1PDGFRB | |
| SCHEMBL18431537 | 0.89 | ABL1 (0.68) | PDGFRAKDRKITABL1PDGFRB | |
| SCHEMBL12627013 | 0.88 | PDGFRA (0.81) | PDGFRAKDRKITABL1PDGFRB | |
| SCHEMBL11927766 | 0.88 | PDGFRA (0.74) | PDGFRAKDRKITABL1PDGFRB | |
| SCHEMBL11927819 | 0.85 | PDGFRA (0.78) | PDGFRAKDRKITABL1PDGFRB | |
| SCHEMBL12627018 | 0.84 | PDGFRA (0.91) | PDGFRAKDRKITABL1PDGFRB | |
| SCHEMBL3636349 | 0.83 | PDGFRA (1.00) | PDGFRAKDRKITABL1PDGFRB | |
| SCHEMBL1653907 | 0.82 | ABL1 (0.75) | PDGFRAKDRKITABL1PDGFRB | |
| SCHEMBL11927817 | 0.81 | PDGFRA (0.92) | PDGFRAKDRKITABL1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10662195-B2 | Protein kinase conjugates and inhibitors | CELGENE CAR LLC (BM) | 2020-05-26 | — | — | US | disclosed |
| US-20170174691-A1 | Protein Kinase Conjugates and Inhibitors | CELGENE CAR LLC (BM) | 2017-06-22 | — | — | US | disclosed |
| US-20170174691-A1 | Protein Kinase Conjugates and Inhibitors | CELGENE CAR LLC (BM) | 2017-06-22 | — | — | US | disclosed |
| US-9556426-B2 | Protein kinase conjugates and inhibitors | CELGENE AVILOMICS RESEARCH, INC. (US) | 2017-01-31 | — | — | US | disclosed |
| US-9556426-B2 | Protein kinase conjugates and inhibitors | CELGENE AVILOMICS RESEARCH, INC. (US) | 2017-01-31 | — | — | US | disclosed |
| US-20110117073-A1 | Protein Kinase Conjugates and Inhibitors | AVILA THERAPEUTICS, INC. (US) | 2011-05-19 | — | — | US | disclosed |
| US-20110117073-A1 | Protein Kinase Conjugates and Inhibitors | AVILA THERAPEUTICS, INC. (US) | 2011-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170174691-A1 | Protein Kinase Conjugates and Inhibitors | MAP3K20, ADK, TTK | PDGFRA 1238/4885KDR 2005/4885KIT 2556/4885 |
| US-10662195-B2 | Protein kinase conjugates and inhibitors | MAP3K20, ADK, TTK | PDGFRA 1238/4885KDR 2005/4885KIT 2556/4885 |
| US-20110117073-A1 | Protein Kinase Conjugates and Inhibitors | MAP3K20, PACSIN2, MAP3K9 | PDGFRA 1302/4885KDR 2212/4885KIT 2566/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.