Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 20/20 | 0.53 |
| ▸ | CCR5 | P51681 | 6/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14998880 | 1.00 | CCR2 (0.53) | CCR2CCR5KCNH2 | |
| SCHEMBL16683740 | 1.00 | CCR2 (0.53) | CCR2CCR5KCNH2 | |
| SCHEMBL14998881 | 1.00 | CCR2 (0.53) | CCR2CCR5KCNH2 | |
| SCHEMBL15849373 | 0.94 | CCR2 (0.58) | CCR2CCR5KCNH2 | |
| SCHEMBL15976603 | 0.94 | CCR2 (0.58) | CCR2CCR5KCNH2 | |
| SCHEMBL15849351 | 0.94 | CCR2 (0.58) | CCR2CCR5KCNH2 | |
| SCHEMBL3071900 | 0.94 | CCR2 (0.58) | CCR2CCR5KCNH2 | |
| SCHEMBL10236005 | 0.94 | CCR2 (0.58) | CCR2CCR5KCNH2 | |
| SCHEMBL14998878 | 0.93 | CCR2 (0.61) | CCR2CCR5KCNH2 | |
| SCHEMBL14998879 | 0.93 | CCR2 (0.61) | CCR2CCR5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513086-B1 | NOVEL ANTAGONISTS FOR CCR2 AND USES THEREOF | BOEHRINGER INGELHEIM INT (DE) | 2015-04-29 | — | — | EP | disclosed |
| WO-2011073155-A1 | NOVEL ANTAGONISTS FOR CCR2 AND USES THEREOF | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-06-23 | — | — | WO | disclosed |