SCHEMBL1263185

SCHEMBL1263185

CCCCC[C](C)C(=O)O

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1B1 P15121 1/20 0.59
GPR84 Q9NQS5 7/20 0.56
PPARG P37231 7/20 0.56
PPARD Q03181 7/20 0.56
PPARA Q07869 7/20 0.56
HDAC11 Q96DB2 5/20 0.56
TSHR P16473 4/20 0.56
PTPN1 P18031 3/20 0.56
ALDH1A1 P00352 2/20 0.56
TLR2 O60603 2/20 0.56
TDP1 Q9NUW8 2/20 0.56
FABP4 P15090 2/20 0.56
KMT2A Q03164 2/20 0.56
SLC22A6 Q4U2R8 1/20 0.56
SLC22A8 Q8TCC7 1/20 0.56
MEN1 O00255 1/20 0.56
ESR1 P03372 1/20 0.56
ALOX15 P16050 1/20 0.56
PDE4A P27815 1/20 0.56
PDE3A Q14432 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8017577 0.92
Oxalic Acid SCHEMBL28834688 0.79 AKR1B1 (0.59) AKR1B1GPR84PPARGPPARDPPARA
SCHEMBL7617367 0.79 TSHR (0.63) AKR1B1GPR84PPARGPPARDPPARA
Oxalic Acid SCHEMBL28884528 0.77 GPR84 (0.61) AKR1B1GPR84PPARGPPARDPPARA
SCHEMBL11459870 0.77 CES1 (0.71) GPR84PPARGPPARDPPARAHDAC11
Hexane SCHEMBL8125919 0.76 AKR1B1 (0.61) AKR1B1GPR84PPARGPPARDPPARA
Hexane SCHEMBL6562722 0.76 AKR1B1 (0.61) AKR1B1GPR84PPARGPPARDPPARA
Hexane SCHEMBL7487068 0.76 AKR1B1 (0.61) AKR1B1GPR84PPARGPPARDPPARA
Hexane SCHEMBL6982515 0.76 AKR1B1 (0.61) AKR1B1GPR84PPARGPPARDPPARA
Hexane SCHEMBL10688418 0.76 AKR1B1 (0.61) AKR1B1GPR84PPARGPPARDPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8211925-B2 Benzamide glucokinase activators TRANSTECH PHARMA, INC. (US) 2012-07-03 US disclosed
US-20110230529-A1 BENZAMIDE GLUCOKINASE ACTIVATORS TRANSTECH PHARMA, INC. (US) 2011-09-22 US disclosed
US-7880012-B2 e.g. 3-[2-(3-Isopropoxy-5-phenoxy-benzoylamino)-thiazol-5-yl-sulfanyl]-propionic acid methyl ester; metabolic disorder, blood glucose lowering, hyperglycemia, impaired glucose tolerance (IGT), Syndrome X, Polycystic Ovarian Syndrome, type I and type II diabetes, dyslipidemia, hyperlipidemia etc. TRANSTECH PHARMA, INC. (US) 2011-02-01 US disclosed
US-20100331379-A1 BENZAMIDE GLUCOKINASE ACTIVATORS VTVX HOLDINGS I LLC 2010-12-30 US disclosed
EP-2019823-B1 BENZAMIDE GLUCOKINASE ACTIVATORS TRANSTECH PHARMA INC (US) 2010-11-24 EP disclosed
US-20090176991-A1 BENZAMIDE GLUCOKINASE ACTIVATORS TRANSTECH PHARMA, LLC 2009-07-09 US disclosed
EP-2019823-A2 BENZAMIDE GLUCOKINASE ACTIVATORS Transtech Pharma, Inc. (US) 2009-02-04 EP disclosed
EP-2019824-A2 BENZAMIDE GLUCOKINASE ACTIVATORS Transtech Pharma, Inc. (US) 2009-02-04 EP disclosed
WO-2007125105-A2 BENZAMIDE GLUCOKINASE ACTIVATORS TRANSTECH PHARMA, INC. (US) 2007-11-08 WO disclosed
WO-2007125103-A2 BENZAMIDE GLUCOKINASE ACTIVATORS TRANSTECH PHARMA, INC. (US) 2007-11-08 WO disclosed
US-5620978-A 8-aza, 6-aza and 6,8-diaza-1,4-dihydroquinoxaline-2,3-diones and the use thereof as antagonists for the glycine/NMDA receptor STATE OF OREGON, ACTING BY AND THROUGH THE OREGON STATE BOARD OF HIGHER EDUCATION, ACTING FOR AND ON BEHALF OF THE OREGON HEALTH SCIENCES UNIVERSITY AND THE UNIVERSITY OF OREGON, EUGENE OREGON (US) 1997-04-15 US disclosed
US-5620979-A TREATING NEURONAL LOSS ASSOCIATED WITH STROKE, ISCHEMIA, CENTRAL NERVOUS SYSTEM TRAUMA, HYPOGLYCEMIA OR SURGERY STATE OF OREGON, ACTING BY AND THROUGH THE OREGON STATE BOARD OF HIGHER EDUCATION, ACTING FOR AND ON BEHALF OF THE OREGON HEALTH SCIENCES UNIVERSITY AND THE UNIVERSITY OF OREGON, EUGENE OREGON (US) 1997-04-15 US disclosed
EP-0743855-A1 8-AZA, 6-AZA AND 6,8-DIAZA-1,4-DIHYDROQUINOXALINE-2,3-DIONES AND THE USE THEREOF AS ANTAGONISTS FOR THE GLYCINE/NMDA RECEPTOR ACEA PHARMACEUTICALS, INC. (US) 1996-11-27 EP disclosed
EP-0732942-A1 ALKYL, AZIDO, ALKOXY, AND FLUORO-SUBSTITUTED AND FUSED QUINOXALINEDIONES AND THE USE THEREOF AS GLYCINE RECEPTOR ANTAGONISTS ACEA PHARMACEUTICALS, INC. (US) 1996-09-25 EP disclosed
US-5514680-A ANTICONVULSANTS WITH 5,6,7-TRISUBSTITUTED-1,4-DIHYDROQUINOXALINE-2,3-DIONE THE STATE OF OREGON, ACTING BY AND THROUGH THE OREGON STATE BOARD OF HIGHER EDUCATION, ACTING FOR AND ON BEHALF OF THE OREGON HEALTH SCIENCES UNIVERSITY (US) 1996-05-07 US disclosed
WO-1995018616-A2 8-AZA, 6-AZA AND 6,8-DIAZA-1,4-DIHYDROQUINOXALINE-2,3-DIONES AND THE USE THEREOF AS ANTAGONISTS FOR THE GLYCINE/NMDA RECEPTOR ACEA PHARM INC (US) 1995-07-13 WO disclosed
WO-1995012417-A1 ALKYL, AZIDO, ALKOXY, AND FLUORO-SUBSTITUTED AND FUSED QUINOXALINEDIONES AND THE USE THEREOF AS GLYCINE RECEPTOR ANTAGONISTS ACEA PHARMACEUTICALS, INC. (US) 1995-05-11 WO disclosed
EP-0647137-A1 GLYCINE RECEPTOR ANTAGONISTS AND THE USE THEREOF THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1995-04-12 EP disclosed
WO-1994012029-A1 USE OF FUSED RING CYCLOPENTANONES AND CYCLOPENTENONES IN CONTROLLING PLANT GROWTH BRITISH TECHNOLOGY GROUP LIMITED (GB) 1994-06-09 WO disclosed
WO-1994000124-A1 GLYCINE RECEPTOR ANTAGONISTS AND THE USE THEREOF WEBER ECKARD (US) 1994-01-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090176991-A1 BENZAMIDE GLUCOKINASE ACTIVATORS GCK, GCKR, KHK AKR1B1 907/4885GPR84 1405/4885PPARG 225/4885
US-20100331379-A1 BENZAMIDE GLUCOKINASE ACTIVATORS GCK, GCKR, HK2 AKR1B1 1069/4885GPR84 1397/4885PPARG 242/4885
US-20110230529-A1 BENZAMIDE GLUCOKINASE ACTIVATORS GCK, GCKR, KHK AKR1B1 907/4885GPR84 1405/4885PPARG 225/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.