Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 15/20 | 0.67 |
| ▸ | EGFR | P00533 | 6/20 | 0.64 |
| ▸ | FLT3 | P36888 | 2/20 | 0.64 |
| ▸ | BLK | P51451 | 2/20 | 0.64 |
| ▸ | JAK2 | O60674 | 1/20 | 0.64 |
| ▸ | JAK1 | P23458 | 1/20 | 0.64 |
| ▸ | TTK | P33981 | 1/20 | 0.64 |
| ▸ | TXK | P42681 | 1/20 | 0.64 |
| ▸ | BTK | Q06187 | 1/20 | 0.64 |
| ▸ | ITK | Q08881 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12635502 | 0.90 | JAK3 (0.66) | JAK3EGFRFLT3BLKJAK2 | |
| SCHEMBL15130607 | 0.87 | JAK3 (0.80) | JAK3EGFRFLT3BLKJAK2 | |
| SCHEMBL12398388 | 0.85 | EGFR (0.74) | JAK3EGFRFLT3BLKJAK2 | |
| SCHEMBL12634350 | 0.85 | JAK3 (0.68) | JAK3EGFRFLT3BLKJAK2 | |
| SCHEMBL12634412 | 0.81 | JAK3 (0.66) | JAK3EGFRFLT3BLKJAK2 | |
| SCHEMBL18501688 | 0.81 | JAK3 (0.80) | JAK3EGFRFLT3BLKJAK2 | |
| SCHEMBL17209827 | 0.80 | JAK3 (1.00) | JAK3EGFRFLT3BLKJAK2 | |
| SCHEMBL17209829 | 0.80 | JAK3 (1.00) | JAK3EGFRFLT3BLKJAK2 | |
| SCHEMBL17209789 | 0.78 | JAK3 (1.00) | JAK3EGFRFLT3BLKJAK2 | |
| SCHEMBL30925312 | 0.78 | JAK3 (1.00) | JAK3EGFRFLT3BLKJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079231-A1 | COMPOUNDS THAT MODULATE EGFR ACTIVITY AND METHODS FOR TREATING OR PREVENTING CONDITIONS THEREWITH | GATEKEEPER PHARMACEUTICAL, INC. (US) | 2011-06-30 | — | — | WO | disclosed |