Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 8/20 | 0.57 |
| ▸ | CHRNA10 | Q9GZZ6 | 8/20 | 0.57 |
| ▸ | CHRNA9 | Q9UGM1 | 8/20 | 0.57 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4398929 | 0.93 | CHRNA7 (0.53) | CHRNA7CHRNA10CHRNA9CHRNB2CHRNB4 | |
| SCHEMBL13231442 | 0.88 | CHRNA7 (0.57) | CHRNA7CHRNA10CHRNA9CHRNB2CHRNB4 | |
| SCHEMBL12637960 | 0.83 | CHRNA7 (0.55) | CHRNA7CHRNA10CHRNA9CHRNB2CHRNB4 | |
| SCHEMBL13334266 | 0.83 | CHRNA7 (0.62) | CHRNA7CHRNA10CHRNA9CHRNB2CHRNB4 | |
| SCHEMBL4400616 | 0.83 | CHRNA7 (0.52) | CHRNA7CHRNA10CHRNA9CHRNB2CHRNB4 | |
| Bromide SCHEMBL3310844 | 0.82 | CHRNA7 (0.63) | CHRNA7CHRNA10CHRNA9CHRNB2CHRNB4 | |
| SCHEMBL4398955 | 0.82 | CHRNA7 (0.64) | CHRNA7CHRNA10CHRNA9CHRNB2CHRNB4 | |
| Bromide SCHEMBL16105104 | 0.81 | CHRNA7 (0.57) | CHRNA7CHRNA10CHRNA9CHRNB2CHRNB4 | |
| SCHEMBL12638052 | 0.80 | CHRNA7 (0.68) | CHRNA7CHRNA10CHRNA9CHRNB2CHRNB4 | |
| SCHEMBL12409003 | 0.79 | CHRNA7 (0.49) | CHRNA7CHRNA10CHRNA9CHRNB2CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8940774-B2 | Tris-Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic Acetylcholine Receptors | UNIV KENTUCKY RES FOUND (US) | 2015-01-27 | — | — | US | disclosed |
| US-8940774-B2 | Tris-Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic Acetylcholine Receptors | UNIV KENTUCKY RES FOUND (US) | 2015-01-27 | — | — | US | disclosed |
| US-8703803-B2 | Tris-quaternary ammonium salts and methods for modulating neuronal nicotinic acetylcholine receptors | UNIV KENTUCKY RES FOUND (US) | 2014-04-22 | — | — | US | disclosed |
| US-8703803-B2 | Tris-quaternary ammonium salts and methods for modulating neuronal nicotinic acetylcholine receptors | UNIV KENTUCKY RES FOUND (US) | 2014-04-22 | — | — | US | disclosed |
| US-20140080866-A1 | Tris-Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic Acetylcholine Receptors | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2014-03-20 | — | — | US | disclosed |
| US-20140080866-A1 | Tris-Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic Acetylcholine Receptors | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2014-03-20 | — | — | US | disclosed |
| US-20130030018-A1 | Tris-Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic Acetylcholine Receptors | UNIV KENTUCKY RES FOUND (US) | 2013-01-31 | — | — | US | disclosed |
| US-8299253-B2 | Tris-quarternary ammonium salts and methods for modulating neuronal nicotinic acetylcholine receptors | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2012-10-30 | — | — | US | disclosed |
| US-20110105556-A1 | TRIS-QUARTERNARY AMMONIUM SALTS AND METHODS FOR MODULATING NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2011-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130030018-A1 | Tris-Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic Acetylcholine Receptors | CHRNA10, CHRNA5, CHRNA2 | CHRNA7 6/4885CHRNA10 1/4885CHRNA9 9/4885 |
| US-20140080866-A1 | Tris-Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic Acetylcholine Receptors | CHRNA4, CHRNA2, CHRNA10 | CHRNA7 7/4885CHRNA10 3/4885CHRNA9 11/4885 |
| US-20110105556-A1 | TRIS-QUARTERNARY AMMONIUM SALTS AND METHODS FOR MODULATING NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS | CHRNA5, CHRNA10, CHRNA4 | CHRNA7 4/4885CHRNA10 2/4885CHRNA9 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.