Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.35 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1264001 | 0.89 | NPC1 (0.45) | NPC1RAB9APOLBLMNAALDH1A1 | |
| SCHEMBL1264046 | 0.88 | NPC1 (0.42) | NPC1RAB9APOLBLMNAALDH1A1 | |
| SCHEMBL1264285 | 0.86 | NPC1 (0.58) | NPC1RAB9APOLBLMNAALDH1A1 | |
| SCHEMBL1263990 | 0.86 | NPC1 (0.42) | NPC1RAB9APOLBLMNAALDH1A1 | |
| SCHEMBL1263980 | 0.86 | NPC1 (0.42) | NPC1RAB9APOLBLMNAALDH1A1 | |
| SCHEMBL2814977 | 0.84 | NPC1 (0.45) | NPC1RAB9APOLBLMNAALDH1A1 | |
| SCHEMBL108807 | 0.81 | NPC1 (0.54) | NPC1RAB9APOLBLMNAALDH1A1 | |
| SCHEMBL30893054 | 0.81 | NPC1 (0.50) | NPC1RAB9APOLBLMNAALDH1A1 | |
| SCHEMBL7574172 | 0.81 | NPC1 (0.50) | NPC1RAB9APOLBLMNAALDH1A1 | |
| SCHEMBL29813370 | 0.81 | NPC1 (0.54) | NPC1RAB9APOLBLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2332013-A1 | ULTRAVIOLET LIGHT ABSORBING KETONES OF 2-(2-HYDROXYPHENYL) BENZOTRIAZOLE | Chang, Chia-Hu (US) | 2011-06-15 | — | — | EP | claimed |
| US-20110038816-A1 | Ultraviolet light absorbing ketones of 2-(2-hydroxyhenyl) benzotriazole | CHANG CHIA-HU | 2011-02-17 | — | — | US | claimed |
| WO-2010039229-A1 | ULTRAVIOLET LIGHT ABSORBING KETONES OF 2-(2-HYDROXYPHENYL) BENZOTRIAZOLE | CHANG CHIA-HU (US) | 2010-04-08 | — | — | WO | claimed |
| US-20100086500-A1 | Ultraviolet light absorbing ketones of 2-(2-Hydroxyphenyl) benzotriazole | CHANG CHIA-HU | 2010-04-08 | — | — | US | claimed |
| US-8163934-B2 | Ultraviolet light absorbing ketones of 2-(2-hydroxyphenyl) benzotriazole | CHANG CHIA-HU (US) | 2012-04-24 | — | — | US | disclosed |
| EP-2332013-A1 | ULTRAVIOLET LIGHT ABSORBING KETONES OF 2-(2-HYDROXYPHENYL) BENZOTRIAZOLE | Chang, Chia-Hu (US) | 2011-06-15 | — | — | EP | disclosed |
| US-20110038816-A1 | Ultraviolet light absorbing ketones of 2-(2-hydroxyhenyl) benzotriazole | CHANG CHIA-HU | 2011-02-17 | — | — | US | disclosed |
| US-7847103-B2 | Ultraviolet light absorbing ketones of 2-(2-hydroxyphenyl) benzotriazole | CHANG CHIA-HU | 2010-12-07 | — | — | US | disclosed |
| WO-2010039229-A1 | ULTRAVIOLET LIGHT ABSORBING KETONES OF 2-(2-HYDROXYPHENYL) BENZOTRIAZOLE | CHANG CHIA-HU (US) | 2010-04-08 | — | — | WO | disclosed |
| US-20100086500-A1 | Ultraviolet light absorbing ketones of 2-(2-Hydroxyphenyl) benzotriazole | CHANG CHIA-HU | 2010-04-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110038816-A1 | Ultraviolet light absorbing ketones of 2-(2-hydroxyhenyl) benzotriazole | HCRTR2, HCRTR1, POLL | NPC1 2019/4885RAB9A 4833/4885POLB 1185/4885 |
| US-20100086500-A1 | Ultraviolet light absorbing ketones of 2-(2-Hydroxyphenyl) benzotriazole | HCRTR2, HCRTR1, PAH | NPC1 1975/4885RAB9A 4829/4885POLB 1169/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.