Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 7/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30373778 | 0.90 | DNM1 (0.50) | NPC1RAB9ASMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL12605216 | 0.88 | EPHX1 (0.40) | NPC1RAB9ASMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL12606830 | 0.85 | NPC1 (0.43) | NPC1RAB9ASMN1; SMN2HPGDCASP1 | |
| SCHEMBL12605258 | 0.81 | DNM1 (0.34) | SMN1; SMN2DNM1 | |
| SCHEMBL7453134 | 0.79 | EPHX1 (0.43) | NPC1RAB9ASMN1; SMN2HPGDCASP1 | |
| SCHEMBL7372859 | 0.79 | EPHX1 (0.43) | NPC1RAB9ASMN1; SMN2HPGDCASP1 | |
| SCHEMBL7786505 | 0.78 | EPHX1 (0.46) | NPC1RAB9ASMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL10724239 | 0.78 | EPHX1 (0.48) | NPC1RAB9ASMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL11060290 | 0.77 | EPHX1 (0.44) | NPC1RAB9ASMN1; SMN2HPGDCASP1 | |
| SCHEMBL15850482 | 0.76 | EPHX1 (0.38) | EPHX1DNM1ACHEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079051-A1 | FUSED HETEROAROMATIC PYRROLIDINONES AS SYK INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-06-30 | — | — | WO | disclosed |