Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 7/20 | 0.46 |
| ▸ | PARP1 | P09874 | 3/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2025260 | 0.88 | GRM2 (0.49) | ACHECHRM4 | |
| SCHEMBL12641816 | 0.86 | HRH3 (0.38) | ACHEPARP1PARP2 | |
| SCHEMBL12443025 | 0.84 | ACHE (0.44) | ACHEPARP1PARP2 | |
| SCHEMBL12641791 | 0.80 | KDR (0.42) | PARP1 | |
| SCHEMBL8271573 | 0.78 | PARP1 (0.36) | ACHEPARP1PARP2 | |
| SCHEMBL12641886 | 0.77 | NMT1 (0.39) | — | |
| SCHEMBL12441831 | 0.76 | PARP1 (0.43) | ACHEPARP1 | |
| SCHEMBL12442982 | 0.76 | ACHE (0.50) | ACHE | |
| SCHEMBL2022243 | 0.76 | GRM2 (0.46) | CHRM4 | |
| SCHEMBL2028582 | 0.74 | GRM2 (0.49) | CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7968570-B2 | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators | ASTRAZENECA AB (SE) | 2011-06-28 | — | — | US | disclosed |