Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 15/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12442851 | 0.96 | CRHR1 (0.55) | CRHR1MAPTSMN1; SMN2SLC29A1 | |
| SCHEMBL12109976 | 0.91 | CRHR1 (0.57) | CRHR1MAPTSMN1; SMN2SLC29A1 | |
| SCHEMBL12644981 | 0.91 | CRHR1 (0.53) | CRHR1MAPTSMN1; SMN2SLC29A1 | |
| SCHEMBL821901 | 0.83 | CRHR1 (0.67) | CRHR1MAPTSMN1; SMN2 | |
| SCHEMBL14355907 | 0.83 | CRHR1 (0.50) | CRHR1MAPTSMN1; SMN2SLC29A1 | |
| SCHEMBL26771575 | 0.83 | CRHR1 (0.50) | CRHR1MAPTSMN1; SMN2SLC29A1 | |
| SCHEMBL13250500 | 0.82 | CRHR1 (0.49) | CRHR1MAPTSMN1; SMN2SLC29A1 | |
| SCHEMBL11469164 | 0.82 | CRHR1 (0.49) | CRHR1MAPTSMN1; SMN2SLC29A1 | |
| SCHEMBL12905000 | 0.82 | CRHR1 (0.54) | CRHR1MAPTSMN1; SMN2SLC29A1 | |
| SCHEMBL5355585 | 0.82 | MAPT (0.50) | CRHR1MAPTSMN1; SMN2SLC29A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2332933-A1 | Epithelial sodium channel (ENaC) inhibitors | Novartis AG (CH) | 2011-06-15 | — | — | EP | disclosed |