CRHR1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL1236411	1.00	20/20
SCHEMBL1237475	1.00	20/20
SCHEMBL1612022	1.00	20/20
SCHEMBL1612247	1.00	20/20
SCHEMBL1612674	1.00	20/20
SCHEMBL1612766	1.00	20/20
SCHEMBL1612768	1.00	20/20
SCHEMBL1612822	1.00	20/20
SCHEMBL1613036	1.00	20/20
SCHEMBL1613049	1.00	20/20
SCHEMBL1613111	1.00	20/20
SCHEMBL1613198	1.00	20/20
SCHEMBL1613223	1.00	20/20
SCHEMBL1613262	1.00	20/20
SCHEMBL1613267	1.00	20/20
SCHEMBL1613269	1.00	20/20
SCHEMBL1613306	1.00	20/20
SCHEMBL1613322	1.00	20/20
SCHEMBL1613335	1.00	20/20
SCHEMBL1613389	1.00	20/20

Clinical trials — most relevant to CRHR1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
The Effect of Corticotrophin-releasing Hormone (CRH) on Esophageal Motility in Healthy Volunteers	PHASE4	COMPLETED
Prednisolone Versus Vigabatrin in the First-line Treatment of Infantile Spasms	PHASE3	WITHDRAWN
Novel Therapeutics in Posttraumatic Stress Disorder (PTSD): A Randomized Clinical Trial of Mifepristone	PHASE2	COMPLETED
Analyzing Female Trauma Exposed Responses to a Medication	PHASE2	COMPLETED
CRF1 Antagonist GSK561679 in Alcoholism	PHASE2	COMPLETED
RESET-medication Glucocorticoid Receptor (GR) Blockade As Disease Modifying Treatment for Depression with Childhood Trauma	PHASE2	COMPLETED
Vagal Nerve Stimulation for Intestinal Barrier Dysfunction in Healthy Volunteers	PHASE1	COMPLETED
Stress, Hormones, and Eating	EARLY_PHASE1	COMPLETED
[C-11]NPA PET-amphetamine in Cocaine Use Disorders	EARLY_PHASE1	RECRUITING
Imaging CRF X NOP Interactions in CUD	EARLY_PHASE1	RECRUITING
CRF - Nociceptin Receptor Interactions	EARLY_PHASE1	COMPLETED
Effects of Hormone Stimulation on Brain Scans for Cushing s Disease	EARLY_PHASE1	COMPLETED
Dose Response Relationship for Single Doses of Corticotropin Releasing Hormone (CRH) in Normal Volunteers and in Patients With Adrenal Insufficiency	nan	COMPLETED
Examination of Brain Serotonin Receptors in Patients With Mood Disorders	nan	COMPLETED
Corticotropin Releasing Hormone (CRH) Responsiveness in Children With Functional Dyspepsia	nan	WITHDRAWN
The Interplay Between Addiction to Tobacco Smoking and Sleep Quality Among Healthy Adults	nan	UNKNOWN
A Proof-of-concept Study Evaluating the Microbiota-gut-brain Axis	nan	RECRUITING
The Effect of Minimal Flow Anesthesia on Oxidative and Neuroendocrine Stress Response	nan	ACTIVE_NOT_RECRUITING
Multi-level Molecular Profiling of High Acute Stress: a Clinical Study	nan	UNKNOWN
Modified Desmopressin (mDesmo) Using Cold-Kit for PET/CT	nan	RECRUITING
Brain Chemical Receptor Effects in Patients With Panic Disorder and Post-Traumatic Stress Disorder	nan	COMPLETED
Effects of Manual Therapy in Fibromyalgia Syndrome	nan	COMPLETED
Identification of Physiological Sleep Indices That Reflect Clinical Improvement and Reduction in Stress Biomarkers After Stellate Ganglion Block in Patients With Posttraumatic Stress Disorder (PTSD)	nan	NOT_YET_RECRUITING
Cortisol, Hippocampus, and Insula in Anorexia Nervosa.	nan	RECRUITING
Salivary Cortisol as Stress Marker in Newborns Subjected to Double Weighing With Physiological Body Weight	nan	COMPLETED
Brain Receptor Function in Post-Traumatic Stress Disorder	nan	COMPLETED
Effects of a Multiple Sclerosis Relapse Therapy on Offspring Neurocognitive Development and Behaviour	nan	UNKNOWN
Adrenocorticotropic Hormone (ACTH) Stimulation and G Protein	nan	COMPLETED
Effects of Hydrocortisone in Patients With Post-Traumatic Stress Disorder	nan	COMPLETED
Does Intravitreal Injection of Triamcinolone Acetonide Impairs the Adrenal Function	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a CRHR1 binder may also engage these)

Protein	Name	Similarity
P35347	—	1.000	P35347 →
Q76LL8	—	1.000	Q76LL8 →
P35353	—	1.000	P35353 →
Q90812	—	0.998	Q90812 →
O62772	—	0.985	O62772 →
Q8WU67	—	0.937	Q8WU67 →
Q0VC00	—	0.934	Q0VC00 →
O42602	—	0.932	O42602 →
GABBR1	Gamma-aminobutyric acid type B receptor subunit 1	0.927	landscape →
O14817	—	0.926	O14817 →
Q9Y2E8	—	0.923	Q9Y2E8 →
Q9Z0U4	—	0.919	Q9Z0U4 →
Q9WV18	—	0.917	Q9WV18 →
Q91ZH7	—	0.916	Q91ZH7 →
Q5RAP3	—	0.915	Q5RAP3 →
GABRG3	Gamma-aminobutyric acid receptor subunit gamm	0.905	landscape →
CRHR2	Corticotropin-releasing factor receptor 2	0.904	landscape →
Q9DCK3	—	0.902	Q9DCK3 →
Q4L208	—	0.900	Q4L208 →
Q5ZJ75	—	0.900	Q5ZJ75 →
Q8R4D1	—	0.898	Q8R4D1 →
P47866	—	0.889	P47866 →
Q90328	—	0.888	Q90328 →
MTAP	S-methyl-5'-thioadenosine phosphorylase	0.884	landscape →
P10063	—	0.883	P10063 →
Q3B8H4	—	0.883	Q3B8H4 →
Q5RF92	—	0.882	Q5RF92 →
Q9UNH6	—	0.882	Q9UNH6 →
GABRA2	Gamma-aminobutyric acid receptor subunit alpha-2	0.882	landscape →
Q3MHL3	—	0.882	Q3MHL3 →