SCHEMBL12647206 — predicted protein targets

Predicted protein targets (top 11)

	gene	UniProt	supporting neighbours	confidence
▸	MKNK1	Q9BUB5	8/20	0.69

▸	MKNK2	Q9HBH9	8/20	0.69

▸	CYP11B2	P19099	2/20	0.58

▸	CYP11B1	P15538	1/20	0.58

▸	MAP4K4	O95819	2/20	0.57

▸	CHEK2	O96017	1/20	0.51

▸	DHODH	Q02127	1/20	0.51

▸	HDAC1	Q13547	2/20	0.51

▸	CHRNA7	P36544	1/20	0.51

▸	DGAT1	O75907	1/20	0.51

▸	SCN10A	Q9Y5Y9	2/20	0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL6754398	0.85	MKNK1 (0.67)	MKNK1MKNK2CYP11B2CYP11B1MAP4K4
SCHEMBL1785559	0.84	MKNK1 (0.68)	MKNK1MKNK2CYP11B2CYP11B1MAP4K4
SCHEMBL28760070	0.84	MKNK1 (0.57)	MKNK1MKNK2CYP11B2CYP11B1MAP4K4
SCHEMBL13770291	0.83	MKNK1 (0.69)	MKNK1MKNK2CYP11B2CYP11B1MAP4K4
SCHEMBL27986242	0.83	MKNK1 (0.87)	MKNK1MKNK2CYP11B2CYP11B1MAP4K4
SCHEMBL2488476	0.82	MKNK1 (0.77)	MKNK1MKNK2CYP11B2CYP11B1MAP4K4
SCHEMBL30108186	0.82	MKNK1 (0.65)	MKNK1MKNK2CYP11B2CYP11B1MAP4K4
SCHEMBL29870407	0.82	MAP4K4 (0.83)	MKNK1MKNK2CYP11B2CYP11B1MAP4K4
SCHEMBL1758530	0.82	MAP4K4 (0.83)	MKNK1MKNK2CYP11B2CYP11B1MAP4K4
SCHEMBL30108216	0.82	DHODH (0.60)	MKNK1MKNK2CYP11B2CYP11B1MAP4K4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-7943643-B2	Aryl substituted pyridines and the use thereof	PURDUE PHARMA L.P. (US)	2011-05-17	—	—	US	disclosed