Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 4/20 | 0.44 |
| ▸ | HTR2A | P28223 | 3/20 | 0.44 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.43 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.43 |
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | PHGDH | O43175 | 1/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | KMO | O15229 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12654400 | 0.97 | P2RX1 (0.46) | CA2CA9HTR2CHTR2AP2RX1 | |
| SCHEMBL12654101 | 0.94 | HTR2C (0.51) | CA2CA9HTR2CHTR2AHTR2B | |
| SCHEMBL12654423 | 0.88 | CA2 (0.44) | CA2CA9HTR2CHTR2AP2RX1 | |
| SCHEMBL12654666 | 0.88 | FGFR4 (0.49) | CA2CA9HTR2CHTR2AFGFR4 | |
| SCHEMBL12654664 | 0.87 | FGFR4 (0.42) | CA2CA9HTR2CHTR2AP2RX1 | |
| SCHEMBL1812175 | 0.86 | CNR1 (0.43) | HTR2CHTR2AFGFR4GPR142CREBBP | |
| SCHEMBL16776476 | 0.86 | CA2 (0.43) | CA2CA9HTR2CHTR2AHTR2B | |
| SCHEMBL12654527 | 0.86 | FGFR4 (0.56) | CA2CA9HTR2CHTR2AFGFR4 | |
| SCHEMBL12654516 | 0.85 | P2RX1 (0.48) | CA2CA9HTR2CHTR2AP2RX1 | |
| SCHEMBL12654222 | 0.85 | CA2 (0.44) | CA2CA9HTR2CHTR2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9556201-B2 | Bicyclic pyridines and analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-01-31 | — | — | US | disclosed |
| US-9556201-B2 | Bicyclic pyridines and analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-01-31 | — | — | US | disclosed |
| EP-2493888-B1 | BICYCLIC PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2016-04-06 | — | — | EP | disclosed |
| WO-2011059839-A1 | BICYCLIC PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2011-05-19 | — | — | WO | disclosed |