Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 14/20 | 0.48 |
| ▸ | HTR2C | P28335 | 14/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 2/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12654652 | 0.91 | CNR2 (0.39) | HTR2AHTR2CTP53FAAH | |
| SCHEMBL12654654 | 0.87 | CNR1 (0.39) | TP53FAAH | |
| SCHEMBL12654410 | 0.87 | CNR2 (0.36) | HTR2AHTR2CTSHRMAPTFAAH | |
| SCHEMBL12654217 | 0.85 | HTR2C (0.56) | HTR2AHTR2CTSHRTP53POLB | |
| SCHEMBL12654655 | 0.85 | TP53 (0.40) | TP53MAPTFAAH | |
| SCHEMBL1812181 | 0.84 | MPL (0.41) | FAAHCYP11B2 | |
| SCHEMBL12653784 | 0.84 | CNR2 (0.51) | TP53FAAH | |
| SCHEMBL12654219 | 0.83 | FGFR4 (0.43) | CYP11B2 | |
| SCHEMBL12654413 | 0.82 | GRM5 (0.45) | — | |
| SCHEMBL1811047 | 0.82 | HTR2C (0.50) | HTR2AHTR2CTSHRTP53POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9556201-B2 | Bicyclic pyridines and analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-01-31 | — | — | US | disclosed |
| US-9556201-B2 | Bicyclic pyridines and analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-01-31 | — | — | US | disclosed |
| EP-2493888-B1 | BICYCLIC PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2016-04-06 | — | — | EP | disclosed |
| WO-2011059839-A1 | BICYCLIC PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2011-05-19 | — | — | WO | disclosed |