Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.45 |
| ▸ | FPR2 | P25090 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 3/20 | 0.38 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12654654 | 0.90 | CNR1 (0.39) | CNR2CNR1PTGER4 | |
| SCHEMBL12653784 | 0.88 | CNR2 (0.51) | GRM5CNR2CNR1 | |
| SCHEMBL12654412 | 0.86 | GCK (0.44) | GRM5CNR2CNR1RAB9A | |
| SCHEMBL12654655 | 0.86 | TP53 (0.40) | CNR2CNR1 | |
| SCHEMBL12654219 | 0.85 | FGFR4 (0.43) | GRM5CNR2CNR1CYP3A4 | |
| SCHEMBL1812181 | 0.85 | MPL (0.41) | GRM5CNR2CNR1 | |
| SCHEMBL12654652 | 0.84 | CNR2 (0.39) | GRM5CNR2CNR1CYP3A4 | |
| SCHEMBL17655345 | 0.84 | GRM5 (0.48) | GRM5FPR2CNR2CNR1RAB9A | |
| SCHEMBL18415690 | 0.83 | GRM5 (0.34) | GRM5CNR2CNR1 | |
| SCHEMBL12654653 | 0.82 | HTR2A (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9556201-B2 | Bicyclic pyridines and analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-01-31 | — | — | US | disclosed |
| US-9556201-B2 | Bicyclic pyridines and analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-01-31 | — | — | US | disclosed |
| EP-2493888-B1 | BICYCLIC PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2016-04-06 | — | — | EP | disclosed |
| WO-2011059839-A1 | BICYCLIC PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2011-05-19 | — | — | WO | disclosed |