Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | SNCA | P37840 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 3/20 | 0.38 |
| ▸ | MAP2 | P11137 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 2/20 | 0.36 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.36 |
| ▸ | LCK | P06239 | 2/20 | 0.36 |
| ▸ | CSF1R | P07333 | 2/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.36 |
| ▸ | KIT | P10721 | 2/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.36 |
| ▸ | FLT1 | P17948 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | FLT3 | P36888 | 2/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21902715 | 0.80 | DYRK1A (0.38) | JAK2CLK1DYRK2FLT1KDR | |
| SCHEMBL24780533 | 0.78 | JAK2 (0.51) | JAK2CYP2C9CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL14883424 | 0.77 | JAK2 (0.54) | JAK2CYP2C9CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL1666074 | 0.77 | JAK2 (0.54) | JAK2CYP2C9CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL29928376 | 0.77 | JAK2 (0.54) | JAK2CYP2C9CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL15155041 | 0.77 | GSK3B (0.56) | JAK2CYP2C9CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL1053943 | 0.77 | JAK2 (0.58) | JAK2CYP2C9CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL21902710 | 0.77 | CYP2C19 (0.40) | CYP2C9CYP3A4CYP2C19BRAFCLK1 | |
| SCHEMBL14685266 | 0.77 | CLK1 (0.39) | JAK2CYP2C9CYP3A4CYP2D6CLK1 | |
| SCHEMBL24781572 | 0.77 | JAK2 (0.50) | JAK2CYP2C9CYP3A4CYP2C19SNCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3141548-B1 | PROCESSES AND INTERMEDIATES FOR PRODUCING AZAINDOLES | VERTEX PHARMA (US) | 2020-04-08 | — | — | EP | disclosed |
| EP-2332940-B1 | Azaindoles useful as inhibitors of JAK and other protein kinases | VERTEX PHARMA (US) | 2012-10-31 | — | — | EP | disclosed |
| EP-1730146-B1 | AZAINDOLES USEFUL AS INHIBITORS OF JAK AND OTHER PROTEIN KINASES | VERTEX PHARMA (US) | 2011-05-04 | — | — | EP | disclosed |