Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.67 |
| ▸ | KIT | P10721 | 10/20 | 0.65 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.63 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.61 |
| ▸ | CDC7 | O00311 | 3/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.53 |
| ▸ | PIM1 | P11309 | 2/20 | 0.53 |
| ▸ | PRKACA | P17612 | 2/20 | 0.53 |
| ▸ | CDK2 | P24941 | 2/20 | 0.53 |
| ▸ | GSK3B | P49841 | 2/20 | 0.53 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.53 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 2/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.52 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.52 |
| ▸ | PAK4 | O96013 | 1/20 | 0.52 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12572822 | 0.90 | BRD4 (0.70) | BRD4KITNTRK1DYRK1ACDC7 | |
| SCHEMBL857208 | 0.88 | BRD4 (0.76) | BRD4KITDYRK1APIK3CA | |
| SCHEMBL857533 | 0.85 | DYRK1A (0.68) | BRD4KITDYRK1ACDC7ROCK2 | |
| SCHEMBL1665897 | 0.82 | CAMKK2 (0.61) | BRD4KITDYRK1ACDC7FLT3 | |
| SCHEMBL1666096 | 0.82 | BRD4 (0.70) | BRD4KITDYRK1ACDC7ROCK2 | |
| SCHEMBL1666437 | 0.81 | BRD4 (0.62) | BRD4KITDYRK1ACDC7ROCK2 | |
| SCHEMBL1666739 | 0.80 | BRD4 (1.00) | BRD4KITDYRK1ACDC7ROCK2 | |
| SCHEMBL30663475 | 0.80 | BRD4 (1.00) | BRD4KITDYRK1ACDC7ROCK2 | |
| SCHEMBL1666076 | 0.80 | BRD4 (0.63) | BRD4KITDYRK1ACDC7FLT3 | |
| SCHEMBL1666515 | 0.79 | BRD4 (0.66) | BRD4KITDYRK1ACDC7ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2332940-B1 | Azaindoles useful as inhibitors of JAK and other protein kinases | VERTEX PHARMA (US) | 2012-10-31 | — | — | EP | disclosed |
| EP-1730146-B1 | AZAINDOLES USEFUL AS INHIBITORS OF JAK AND OTHER PROTEIN KINASES | VERTEX PHARMA (US) | 2011-05-04 | — | — | EP | disclosed |