CAMKK2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL50486	0.47	9/20
SCHEMBL3806	0.43	6/20
Ucn-01 (SCHEMBL259162)	1.00	4/20
SCHEMBL147422	0.66	4/20
SCHEMBL144979	0.56	4/20
SCHEMBL182560	0.52	4/20
SCHEMBL182932	0.52	4/20
SCHEMBL252851	0.39	4/20
SCHEMBL252852	0.39	4/20
SCHEMBL146734	0.67	3/20
SCHEMBL144651	0.67	3/20
SCHEMBL146677	0.67	3/20
SCHEMBL144378	0.66	3/20
SCHEMBL142020	0.65	3/20
SCHEMBL148704	0.62	3/20
SCHEMBL147730	0.61	3/20
SCHEMBL148478	0.61	3/20
SCHEMBL144118	0.61	3/20
SCHEMBL144615	0.61	3/20
SCHEMBL147715	0.61	3/20

Clinical trials — most relevant to CAMKK2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
COMS for Chronic Ulcers Treatment	PHASE4	RECRUITING
Multimodal Versus Opioid aNalgesia in carDiAc Surgery	PHASE4	COMPLETED
Short-Term Metformin Use in Young, Healthy Adults: Impacts on Exercise Capacity	PHASE4	COMPLETED
The G Protein-Coupled Receptor Kinase Type 2 Inhibitor Paroxetine as Adjunctive Therapy to Improve Insulin Sensitivity in Patients With Type 2 Diabetes Mellitus	PHASE3	UNKNOWN
Evaluate Efficacy and Safety of Endoxifen in Bipolar I Disorder Patients	PHASE3	COMPLETED
Efficacy and Safety of Endoxifen in Bipolar I Disorder Patients	PHASE3	ACTIVE_NOT_RECRUITING
The Phosphodiesterase 4 Inhibitor Roflumilast as an Adjunct to Antidepressants in Major Depressive Disorder Patients	PHASE1/PHASE2	WITHDRAWN
Anti-Estrogens - A Potential Treatment for Bipolar Affective Disorder in Women?	PHASE2	COMPLETED
Calcium Channel Blockade in Primary Aldosteronism	PHASE2	COMPLETED
Targeted Therapy With Glycogen Synthase Kinase-3 Inhibition for Arrhythmogenic Cardiomyopathy	PHASE2	RECRUITING
Antidepressant Effects on cAMP Specific Phosphodiesterase (PDE4) in Depressed Patients	PHASE1	COMPLETED
Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans	PHASE1	COMPLETED
Sirolomus Adjuvant Treatment of Focal Refractory Epilepsy (SATFRE)	EARLY_PHASE1	RECRUITING
Role of Nitric Oxide in Diabetic Patients With Erectile Dysfunction	nan	COMPLETED
Influence of Pulse Electromagnetic Field Therapy on Myocardial Ischemia	nan	RECRUITING
Intravenous Terbutaline in Severe Status Asthmaticus	nan	UNKNOWN
Glycine and Magnesium+Thiamine for the Treatment of Primary Ciliary Dyskinesia	nan	RECRUITING
Evaluation of Vasopressin in the Vessels of Ovarian Neoplasms	nan	COMPLETED
Ischemic Preconditioning to Prevent Acute Kidney Injury	nan	COMPLETED
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation	nan	COMPLETED
Pompe & Pain - Study to Assess Nociceptive Pain in Adult Patients With Pompe Disease	nan	UNKNOWN
Exercise in Type 1 Diabetes Mellitus	nan	COMPLETED
Early Detection of Cardiomyopathy by Speckle Echo, High Sensitive Troponin and Cardiac Ryanodine Receptors	nan	UNKNOWN
Role of Amino Acids and Genetic Disorder in Pathogenesis of Heart Failure	nan	UNKNOWN
The Phosphodiesterase-3 Inhibitor Cilostazol as an Adjunctive to Antidepressants in Patients With Major Depressive Disorder.	nan	COMPLETED
Hemodynamic Assessment of underLying myocyTe Function in Right Heart Failure	nan	RECRUITING
Effect of Ivabradine on Levcromakalim-Induced Symptoms in Individuals With Migraine Without Aura (ILIM)	nan	COMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
Effect of Age on Glucose and Lipid Metabolism	nan	COMPLETED
Effect of Metformin on Chronic Pain After Thoracic Surgery in Diabetic Patients	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a CAMKK2 binder may also engage these)

Protein	Name	Similarity
O88831	—	1.000	O88831 →
Q8C078	—	1.000	Q8C078 →
Q8VBY2	—	0.992	Q8VBY2 →
Q68UT7	—	0.992	Q68UT7 →
Q60700	—	0.992	Q60700 →
Q66HE5	—	0.991	Q66HE5 →
Q3ULB5	—	0.991	Q3ULB5 →
Q8K330	—	0.991	Q8K330 →
P97756	—	0.990	P97756 →
Q8BWQ5	—	0.990	Q8BWQ5 →
Q8BZN4	—	0.990	Q8BZN4 →
CAMKK1	Calcium/calmodulin-dependent protein kinase kinase 1	0.990	landscape →
Q63553	—	0.989	Q63553 →
Q924U5	—	0.989	Q924U5 →
D3ZML2	—	0.989	D3ZML2 →
Q641K5	—	0.989	Q641K5 →
DYRK1B	Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0.989	landscape →
STK32C	Serine/threonine-protein kinase 32C	0.989	landscape →
NUAK1	NUAK family SNF1-like kinase 1	0.989	landscape →
SIK1	Serine/threonine-protein kinase SIK1	0.988	landscape →
Q60670	—	0.988	Q60670 →
HIPK4	Homeodomain-interacting protein kinase 4	0.988	landscape →
MAP3K9	Mitogen-activated protein kinase kinase kinase 9	0.988	landscape →
P20689	—	0.988	P20689 →
NUAK2	NUAK family SNF1-like kinase 2	0.988	landscape →
Q9Z188	—	0.988	Q9Z188 →
Q5R7G9	—	0.987	Q5R7G9 →
Q3UIZ8	—	0.987	Q3UIZ8 →
TESK2	Dual specificity testis-specific protein kinase 2	0.987	landscape →
O70405	—	0.987	O70405 →