Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | MTOR | P42345 | 2/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SGK1 | O00141 | 1/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.43 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.43 |
| ▸ | DMPK | Q09013 | 1/20 | 0.43 |
| ▸ | MYLK | Q15746 | 1/20 | 0.43 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL357618 | 0.80 | TSHR (0.53) | HIF1AMAPTROCK2ROCK1SMN1; SMN2 | |
| SCHEMBL356085 | 0.78 | ROCK2 (0.46) | HIF1AMAPTROCK2ROCK1SMN1; SMN2 | |
| SCHEMBL13984317 | 0.76 | ERCC1 (0.60) | HIF1AMAPTMTORROCK2ROCK1 | |
| SCHEMBL14289839 | 0.74 | CYP1A2 (0.53) | HIF1AMAPTROCK2ROCK1SGK1 | |
| SCHEMBL25709720 | 0.73 | MTOR (0.62) | HIF1AMAPTMTORROCK2ROCK1 | |
| SCHEMBL359215 | 0.72 | ROCK2 (0.46) | HIF1AMAPTROCK2ROCK1SMN1; SMN2 | |
| SCHEMBL22026435 | 0.71 | CYP1A2 (0.62) | HIF1AMAPTROCK2ROCK1KMT2A | |
| SCHEMBL358332 | 0.71 | CYP1A2 (0.61) | HIF1AMAPTROCK2ROCK1KMT2A | |
| SCHEMBL31724652 | 0.71 | CYP1A2 (0.56) | HIF1AMAPTROCK2ROCK1KMT2A | |
| SCHEMBL5725833 | 0.71 | CYP1A2 (0.56) | HIF1AMAPTROCK2ROCK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2322525-A1 | Purine derivatives for use as adenosin A2A receptor agonists | Novartis AG (CH) | 2011-05-18 | — | — | EP | disclosed |