Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | OGA | O60502 | 5/20 | 0.43 |
| ▸ | HEXB | P07686 | 5/20 | 0.43 |
| ▸ | HEXA | P06865 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.42 |
| ▸ | FLT4 | P35916 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12660332 | 0.94 | SIRT1 (0.54) | SIRT1L3MBTL1OGAHEXBHEXA | |
| SCHEMBL12660681 | 0.91 | SIRT1 (0.51) | SIRT1L3MBTL1OGAHEXBHEXA | |
| SCHEMBL12660337 | 0.91 | SIRT1 (0.45) | SIRT1KDM4EALDH1A1LMNAL3MBTL1 | |
| SCHEMBL12660345 | 0.90 | SIRT1 (0.50) | SIRT1KDM4EALDH1A1LMNAL3MBTL1 | |
| SCHEMBL12660340 | 0.90 | SIRT1 (0.62) | SIRT1OGAHEXBHEXADYRK3 | |
| SCHEMBL12660431 | 0.89 | SIRT1 (0.48) | SIRT1ALDH1A1LMNAL3MBTL1OGA | |
| SCHEMBL12660234 | 0.88 | KDM4E (0.40) | SIRT1KDM4EALDH1A1LMNAL3MBTL1 | |
| SCHEMBL12660471 | 0.86 | MEN1 (0.47) | SIRT1KDM4EALDH1A1LMNAL3MBTL1 | |
| SCHEMBL12660352 | 0.86 | SIRT1 (0.51) | SIRT1OGAHEXBHEXADYRK3 | |
| SCHEMBL12660684 | 0.85 | DYRK3 (0.46) | SIRT1L3MBTL1OGAHEXBHEXA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7947839-B2 | Heterocyclic-substituted bis-1,8 naphthalimide compounds, antibody drug conjugates, and methods of use | GENENTECH, INC. (US) | 2011-05-24 | — | — | US | disclosed |