Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | MGAM | O43451 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | SI | P14410 | 3/20 | 0.38 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12665049 | 0.92 | CYP2C8 (0.58) | KMT2ACYP2C8MAPTMEN1ALDH1A1 | |
| SCHEMBL12665793 | 0.91 | CYP2C8 (0.47) | KMT2ACYP2C8MAPTMEN1ALDH1A1 | |
| SCHEMBL12665803 | 0.88 | MAPT (0.47) | KMT2AMAPTMEN1ALDH1A1KDM4E | |
| SCHEMBL831577 | 0.87 | CYP2C8 (0.46) | KMT2ACYP2C8MAPTMEN1ALDH1A1 | |
| SCHEMBL833144 | 0.86 | CYP2C8 (0.45) | KMT2ACYP2C8MAPTMEN1ALDH1A1 | |
| SCHEMBL12665807 | 0.86 | CYP2C8 (0.43) | KMT2ACYP2C8MAPTMEN1ALDH1A1 | |
| SCHEMBL12665496 | 0.85 | CYP2C8 (0.55) | KMT2ACYP2C8MAPTMEN1ALDH1A1 | |
| SCHEMBL831703 | 0.84 | CYP2C8 (0.44) | KMT2ACYP2C8MAPTMEN1ALDH1A1 | |
| SCHEMBL831674 | 0.83 | CYP2C8 (0.43) | KMT2ACYP2C8MAPTMEN1ALDH1A1 | |
| SCHEMBL12665086 | 0.83 | CYP2C8 (0.55) | KMT2ACYP2C8MAPTMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110104110-A1 | SUBSTITUTED INDOLE DERIVATIVES AND METHODS OF USE THEREOF | SHERING CORPORATION | 2011-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110104110-A1 | SUBSTITUTED INDOLE DERIVATIVES AND METHODS OF USE THEREOF | IDO1, IDO2, INMT | KMT2A 537/4885CYP2C8 457/4885MAPT 1061/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.