INMT

Indolethylamine N-methyltransferase · O95050 · INMT on Sugi Atlas →

3,303 patent compounds predicted against INMT, 1,903 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL1590233	0.57	7/20
SCHEMBL8539868	0.56	7/20
Bicarbonate (SCHEMBL6363121)	0.84	6/20
Bicarbonate (SCHEMBL6183133)	0.83	6/20
Bicarbonate (SCHEMBL6184428)	0.81	6/20
Formic Acid (SCHEMBL1691873)	0.78	6/20
Bicarbonate (SCHEMBL6184424)	0.75	6/20
Bicarbonate (SCHEMBL6233832)	0.75	6/20
Acetic Acid (SCHEMBL2694265)	0.74	6/20
Trifluoroacetic Acid (SCHEMBL1691805)	0.68	6/20
Iodide (SCHEMBL8539638)	0.57	6/20
SCHEMBL8236320	0.52	6/20
SCHEMBL8673154	0.50	6/20
Fumaric Acid (SCHEMBL4771229)	0.44	6/20
Fumaric Acid (SCHEMBL4771239)	0.44	6/20
SCHEMBL2848542	0.83	5/20
SCHEMBL6859946	0.83	5/20
Acetic Acid (SCHEMBL1691544)	0.75	5/20
Acetic Acid (SCHEMBL1691547)	0.75	5/20
Acetic Acid (SCHEMBL1691556)	0.75	5/20

Clinical trials — most relevant to INMT by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Study of add-on Ramelteon Therapy on Sleep and Circadian Rhythm Disruption in Patients With Schizophrenia	PHASE4	COMPLETED
A Trial of CM-AT in Children With Autism With All Levels of FCT (The Blum Study)	PHASE3	COMPLETED
Decitabine/Cedazuridine (INQOVI), an Oral DNA Demethylating Agent, in Subjects With BAP1 Cancer Predisposition Syndrome and Subclinical, Early-Stage Mesothelioma	PHASE2	SUSPENDED
Safety and Efficacy of BMS-986504 in Unresectable Malignant Peripheral Nerve Sheath Tumor	PHASE1/PHASE2	NOT_YET_RECRUITING
PET Imaging of Dopamine in Healthy Study Participants	PHASE2	COMPLETED
A Multi-Histology Phase II Study of 5-Fluoro-2'-Deoxycytidine With Tetrahydrouridine (FdCyd + THU)	PHASE2	COMPLETED
Phase I Trial of 4'-Thio-2'-Deoxycytidine (TdCyd) in Patients With Advanced Solid Tumors	PHASE1	COMPLETED
5-aza-4'-Thio-2'-Deoxycytidine (Aza-TdC) in People With Advanced Solid Tumors	PHASE1	RECRUITING
Melatonin in Pregnancy	nan	COMPLETED
A Study of the Interaction Between Tumor Susceptibility Gene Glycine N-methyltransferase (GNMT) and Lung Cancer	nan	UNKNOWN
In Vivo Assessment of Histamine Pharmacodynamics	nan	WITHDRAWN
Vancomycin Associated Red Man Syndrome (RMS)	nan	COMPLETED
TSK (Tryptophan - Serotonin - Kynurenine) Biomarkers Assessment in Stroke	nan	COMPLETED
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation	nan	COMPLETED
Estrogen Receptor 1 Gene Polymorphism Frequency in Fibromyalgia Syndrome	nan	COMPLETED
Cancer and Hearing Loss Related in Children	nan	COMPLETED
Efficacy of Essential Phospholipid Versus Betaine HCL/L-Glutamic Acid in MAFLD	nan	NOT_YET_RECRUITING
Investigation of Methylation of EGFR in the Response of the Cetuximab in Metastatic Colorectal Cancer Patients	nan	COMPLETED
The Molecular Pathogenesis Study of Cataract	nan	UNKNOWN
Histamine Pharmacogenetics in Children With Atopic Dermatitis	nan	COMPLETED
An Assessment of Cognitive Function in Irritable Bowel Syndrome	nan	UNKNOWN
Plant-based Diets and Body Weight and Selected Metabolic Parameters Management in Obese Patients.	nan	COMPLETED
Effects of Photobiomodulation Therapy Combined With Static Magnetic Field in Patients With Lateral Epicondylitis	nan	COMPLETED
Adenosylmethionine Metabolism in Human Inflammation	nan	UNKNOWN
Role and Interactions of Adenosine, Receptors, Methionine Cycle Nutritional, Metabolic and Genetic Determinants in the Onset of Atrial Fibrillation in Normal Heart	nan	UNKNOWN
Analysis of DNA Methylation in Spondyloarthritis	nan	COMPLETED
DNA Methylation and Autoimmune Thyroid Diseases	nan	COMPLETED
The Clinical Value of the Nitric Oxide System Components in Asthma and COPD	nan	UNKNOWN
Genetic Variants Associated With Adolescent Suicide Attempts	nan	COMPLETED
Hydroxymethylation, Incident Type 2 Diabetes and Incident Obesity	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a INMT binder may also engage these)

Protein	Name	Similarity
Q5RFR7	—	1.000	Q5RFR7 →
O97972	—	1.000	O97972 →
NNMT	Nicotinamide N-methyltransferase	1.000	landscape →
P40936	—	0.999	P40936 →
O55239	—	0.995	O55239 →
Q06AV1	—	0.994	Q06AV1 →
P10937	—	0.987	P10937 →
P10938	—	0.986	P10938 →
O55171	—	0.983	O55171 →
PNMT	Phenylethanolamine N-methyltransferase	0.982	landscape →
Q5R8R3	—	0.981	Q5R8R3 →
Q6NTR1	—	0.981	Q6NTR1 →
P40935	—	0.981	P40935 →
A0A5F8AH41	—	0.981	A0A5F8AH41 →
O55137	—	0.981	O55137 →
Q8VDG7	—	0.978	Q8VDG7 →
A5PJN5	—	0.978	A5PJN5 →
Q149M9	—	0.978	Q149M9 →
Q8N9L9	—	0.976	Q8N9L9 →
Q3I5F7	—	0.976	Q3I5F7 →
A9ULG4	—	0.976	A9ULG4 →
P83006	—	0.975	P83006 →
Q5JTZ9	—	0.975	Q5JTZ9 →
Q63276	—	0.975	Q63276 →
Q5M876	—	0.975	Q5M876 →
Q9QYR9	—	0.975	Q9QYR9 →
P79106	—	0.975	P79106 →
Q8VDP3	—	0.975	Q8VDP3 →
Q6AYF9	—	0.975	Q6AYF9 →
P0C5J1	—	0.974	P0C5J1 →