Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 2/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 18/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 9/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.49 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.49 |
| ▸ | ERN2 | Q76MJ5 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1638180 | 0.89 | PIK3CB (0.63) | PIK3CBPIK3CDPIK3CAPIK3CGKCNH2 | |
| SCHEMBL1636575 | 0.85 | PRKDC (0.57) | PRKDCPIK3CBPIK3CDPIK3CAPIK3CG | |
| SCHEMBL1639250 | 0.82 | PRKDC (0.55) | PRKDCPIK3CBPIK3CDPIK3CAPIK3CG | |
| SCHEMBL1636854 | 0.80 | PIK3CB (0.67) | PRKDCPIK3CBPIK3CDPIK3CAPIK3CG | |
| SCHEMBL15867056 | 0.78 | PRKDC (0.53) | PRKDCPIK3CBPIK3CDPIK3CAPIK3CG | |
| SCHEMBL27889932 | 0.76 | PRKDC (0.55) | PRKDCPIK3CDPIK3CAPIK3R1 | |
| SCHEMBL13449184 | 0.76 | PRKDC (0.58) | PRKDCPIK3CBPIK3CDPIK3CAPIK3CG | |
| SCHEMBL1637213 | 0.76 | PIK3CB (0.63) | PIK3CBPIK3CDPIK3CAPIK3CGKCNH2 | |
| SCHEMBL12667804 | 0.76 | PIK3CB (0.63) | PIK3CBPIK3CDPIK3CAPIK3CGKCNH2 | |
| SCHEMBL27889939 | 0.76 | PRKDC (0.57) | PRKDCPIK3CBPIK3CDPIK3CAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011051704-A1 | CHROMENONE DERIVATIVES WITH ANTI-TUMOUR ACTIVITY | ASTRAZENECA AB (SE) | 2011-05-05 | — | — | WO | disclosed |