Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 13/20 | 0.57 |
| ▸ | P2RY12 | Q9H244 | 6/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.46 |
| ▸ | XRCC6 | P12956 | 1/20 | 0.46 |
| ▸ | XRCC5 | P13010 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.46 |
| ▸ | MTOR | P42345 | 2/20 | 0.46 |
| ▸ | PDE2A | O00408 | 1/20 | 0.46 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.46 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.46 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | PDE5A | O76074 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28946196 | 0.85 | PIK3CA (0.50) | PRKDCP2RY12PIK3CAPIK3CDXRCC6 | |
| SCHEMBL27873587 | 0.84 | PIK3CB (0.50) | PRKDCPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1636575 | 0.82 | PRKDC (0.57) | PRKDCP2RY12PIK3CAPIK3CDXRCC6 | |
| SCHEMBL27889932 | 0.78 | PRKDC (0.55) | PRKDCP2RY12PIK3CAPIK3CDXRCC6 | |
| SCHEMBL1639250 | 0.77 | PRKDC (0.55) | PRKDCP2RY12PIK3CAPIK3CDPIK3R2 | |
| SCHEMBL1638180 | 0.77 | PIK3CB (0.63) | PIK3CAPIK3CDPIK3R1PIK3CBPIK3CG | |
| SCHEMBL27937987 | 0.77 | PIK3CB (0.46) | PRKDCPIK3CAPIK3CDXRCC6XRCC5 | |
| SCHEMBL27951098 | 0.77 | PIK3CB (0.46) | PRKDCPIK3CAPIK3CDXRCC6XRCC5 | |
| SCHEMBL24714319 | 0.76 | PIK3CB (0.71) | PIK3CAPIK3CDPIK3R1PIK3CBPIK3CG | |
| SCHEMBL15867056 | 0.76 | PRKDC (0.53) | PRKDCPIK3CAPIK3CDPIK3R1PIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104447657-A | CHROMENONE DERIVATIVES WITH ANTI-TUMOUR ACTIVITY | ASTRAZENECA AB | 2015-03-25 | — | — | CN | disclosed |
| CN-102712615-B | Chromenone Derivatives with Antitumor Activity | ASTRAZENECA AB | 2014-12-17 | — | — | CN | disclosed |
| CN-102712615-A | Chromenone Derivatives with Antitumor Activity | ASTRAZENECA AB | 2012-10-03 | — | — | CN | disclosed |