SCHEMBL12669698

SCHEMBL12669698

NS(=O)(=O)CCN1CC[C@@H](O)C1

nearest known ligand 0.38

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
PDCD1 Q15116 1/20 0.38
CD274 Q9NZQ7 1/20 0.38
SMYD3 Q9H7B4 1/20 0.36
LTA4H P09960 1/20 0.35
HRH3 Q9Y5N1 8/20 0.34
HRH2 P25021 2/20 0.34
HRH1 P35367 2/20 0.34
KCNA3 P22001 1/20 0.33
ALDH1A1 P00352 1/20 0.33
GAA P10253 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12669687 1.00 PDCD1 (0.38) PDCD1CD274SMYD3LTA4HHRH3
SCHEMBL12668629 0.89 KCNA3 (0.39) KCNA3ALDH1A1GAA
SCHEMBL12669711 0.86
SCHEMBL5486706 0.83 PDCD1 (0.39) PDCD1CD274SMYD3LTA4HHRH3
SCHEMBL5486709 0.83 PDCD1 (0.39) PDCD1CD274SMYD3LTA4HHRH3
SCHEMBL20058141 0.79 HRH2 (0.38) LTA4HHRH3HRH2HRH1ALDH1A1
SCHEMBL12744447 0.77 KDM1A (0.43) PDCD1CD274SMYD3LTA4HHRH3
SCHEMBL28960037 0.77 PDCD1 (0.44) PDCD1CD274LTA4HHRH3HRH2
SCHEMBL20057817 0.74 ALDH1A1 (0.35) LTA4HHRH3ALDH1A1GAA
SCHEMBL1361941 0.74

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015066515-A1 SELECTIVE SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND COMBINATION THERAPY THEREWITH RECEPTOS, INC. (US) 2015-05-07 WO disclosed
WO-2011060392-A1 SELECTIVE SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND METHODS OF CHIRAL SYNTHESIS RECEPTOS, INC. (US) 2011-05-19 WO disclosed