Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12638273 | 1.00 | NR3C1 (0.66) | NR3C1GLUL | |
| SCHEMBL12947476 | 0.92 | NR3C1 (0.66) | NR3C1GLUL | |
| SCHEMBL12917976 | 0.92 | NR3C1 (0.66) | NR3C1GLUL | |
| SCHEMBL12956594 | 0.90 | NR3C1 (0.64) | NR3C1GLUL | |
| SCHEMBL12918121 | 0.86 | NR3C1 (0.60) | NR3C1GLUL | |
| SCHEMBL12956264 | 0.86 | NR3C1 (0.69) | NR3C1GLUL | |
| SCHEMBL12918118 | 0.86 | NR3C1 (0.59) | NR3C1GLUL | |
| SCHEMBL13049222 | 0.85 | NR3C1 (0.63) | NR3C1GLUL | |
| SCHEMBL12918008 | 0.85 | NR3C1 (0.61) | NR3C1GLUL | |
| SCHEMBL12917998 | 0.85 | NR3C1 (0.61) | NR3C1GLUL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8299048-B2 | Hexahydrocyclopentyl[f]indazole sulfonamides and derivatives thereof as selective glucocorticoid receptor modulators | MERCK SHARP & DOHME CORP. (US) | 2012-10-30 | — | — | US | disclosed |
| US-20110105440-A1 | HEXAHYDROCYCLOPENTYL[f]INDAZOLE SULFONAMIDES AND DERIVATIVES THEREOF AS SELECTIVE GLUCOCORTICOID RECEPTOR MODULATORS | MERCK & CO., INC. | 2011-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105440-A1 | HEXAHYDROCYCLOPENTYL[f]INDAZOLE SULFONAMIDES AND DERIVATIVES THEREOF AS SELECTIVE GLUCOCORTICOID RECEPTOR MODULATORS | NR3C1, NR3C2, GRK5 | NR3C1 1/4885GLUL 2731/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.