Sugi Predict

Sugi Predict / Compounds / SCHEMBL1267263

SCHEMBL1267263

SCHEMBL1267263

FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncccc34)cn2)cn1

nearest known ligand 0.79

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CSF1R P07333 4/20 0.79
▸ KIT P10721 4/20 0.79
▸ CYP2C19 P33261 5/20 0.72
▸ LCK P06239 1/20 0.72
▸ PGR P06401 1/20 0.72
▸ CHRM2 P08172 1/20 0.72
▸ HTR1A P08908 1/20 0.72
▸ ADRA2A P08913 1/20 0.72
▸ PDGFRB P09619 1/20 0.72
▸ ADORA3 P0DMS8 1/20 0.72
▸ CHRM1 P11229 1/20 0.72
▸ PDGFRA P16234 1/20 0.72
▸ FLT1 P17948 1/20 0.72
▸ DRD1 P21728 1/20 0.72
▸ TBXA2R P21731 1/20 0.72
▸ SLC6A2 P23975 1/20 0.72
▸ ADORA1 P30542 1/20 0.72
▸ SLC6A4 P31645 1/20 0.72
▸ ADRA1A P35348 1/20 0.72
▸ OPRM1 P35372 1/20 0.72

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1886559 0.89 CSF1R (0.63) CSF1RKITCYP2C19LCKPGR
SCHEMBL29431664 0.88 CSF1R (1.00) CSF1RKITCYP2C19LCKPGR
SCHEMBL1268018 0.88 CSF1R (1.00) CSF1RKITCYP2C19LCKPGR
Hydrochloric Acid SCHEMBL29973836 0.88 CSF1R (0.98) CSF1RKITCYP2C19LCKPGR
Hydrochloric Acid SCHEMBL20166201 0.88 CSF1R (0.98) CSF1RKITCYP2C19LCKPGR
SCHEMBL1267493 0.87 CYP3A4 (0.74) CSF1RKITCYP2C19LCKPGR
SCHEMBL19898655 0.87 CSF1R (0.74) CSF1RKITCYP2C19LCKPGR
SCHEMBL1266877 0.86 CYP3A4 (0.60) CSF1RKITCYP2C19LCKPGR
SCHEMBL1267815 0.86 CSF1R (0.73) CSF1RKITCYP2C19LCKPGR
SCHEMBL2113768 0.85 CSF1R (0.72) CSF1RKITCYP2C19LCKPGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103917235-A Kinase modulation and indications therefor PLEXXIKON INC 2014-07-09 — — CN claimed
CN-101605787-B Compounds that modulate c-fms and/or c-kit activity and uses thereof PLEXXIKON INC 2013-11-13 — — CN claimed
US-20130274259-A1 KINASE MODULATION AND INDICATIONS THEREFOR DAIICHI SANKYO, INC. 2013-10-17 — — US claimed
US-8461169-B2 Compounds modulating c-fms and/or c-kit activity PLEXXIKON INC. (US) 2013-06-11 — — US claimed
US-20110230482-A1 COMPOUNDS MODULATING C-FMS AND/OR C-KIT ACTIVITY PLEXXIKON INC. 2011-09-22 — — US claimed
US-7893075-B2 Compounds modulating c-fms and/or c-kit activity and uses therefor PLEXXIKON, INC. (US) 2011-02-22 — — US claimed
CN-101605787-A Compounds that modulate c-fms and/or c-kit activity and uses thereof PLEXXIKON INC (US) 2009-12-16 — — CN claimed
US-20090076046-A1 Compounds modulating c-fms and/or c-kit activity and uses therefor PLEXXIKON INC 2009-03-19 — — US claimed
WO-2008064265-A2 COMPOUNDS MODULATING C-FMS AND/OR C-KIT ACTIVITY AND USES THEREFOR PLEXXIKON, INC. (US) 2008-05-29 — — WO claimed
EP-4295912-A2 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR Daiichi Sankyo, Inc. (US) 2023-12-27 — — EP disclosed
US-10806737-B2 Compounds and methods for the targeted degradation of fetal liver kinase polypeptides ARVINAS OPERATIONS, INC. (US) 2020-10-20 — — US disclosed
US-20190263800-A1 COMPOUNDS MODULATING C-FMS AND/OR C-KIT ACTIVITY AND USES THEREFOR PLEXXIKON INC. 2019-08-29 — — US disclosed
US-20190263800-A1 COMPOUNDS MODULATING C-FMS AND/OR C-KIT ACTIVITY AND USES THEREFOR PLEXXIKON INC. 2019-08-29 — — US disclosed
US-10123998-B2 Kinase modulation, and indications therefor PLEXXIKON INC. (US) 2018-11-13 — — US disclosed
WO-2011057022-A1 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR PLEXXIKON, INC. (US) 2011-05-12 — — WO disclosed
US-7893075-B2 Compounds modulating c-fms and/or c-kit activity and uses therefor PLEXXIKON, INC. (US) 2011-02-22 — — US disclosed
US-7893075-B2 Compounds modulating c-fms and/or c-kit activity and uses therefor PLEXXIKON, INC. (US) 2011-02-22 — — US disclosed
CN-101605787-A Compounds that modulate c-fms and/or c-kit activity and uses thereof PLEXXIKON INC (US) 2009-12-16 — — CN disclosed
US-20090076046-A1 Compounds modulating c-fms and/or c-kit activity and uses therefor PLEXXIKON INC 2009-03-19 — — US disclosed
US-20090076046-A1 Compounds modulating c-fms and/or c-kit activity and uses therefor PLEXXIKON INC 2009-03-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10123998-B2 Kinase modulation, and indications therefor FLT3, FLT4, FLT1 CSF1R 147/4885KIT 33/4885CYP2C19 3521/4885
US-20130274259-A1 KINASE MODULATION AND INDICATIONS THEREFOR FLT3, MET, BTK CSF1R 33/4885KIT 138/4885CYP2C19 4477/4885
US-20090076046-A1 Compounds modulating c-fms and/or c-kit activity and uses therefor KIT, FLT3, FLT1 CSF1R 4/4885KIT 1/4885CYP2C19 3327/4885
US-20110230482-A1 COMPOUNDS MODULATING C-FMS AND/OR C-KIT ACTIVITY KIT, FLT3, FER CSF1R 10/4885KIT 1/4885CYP2C19 3400/4885
US-20190263800-A1 COMPOUNDS MODULATING C-FMS AND/OR C-KIT ACTIVITY AND USES THEREFOR KIT, FLT3, FLT1 CSF1R 4/4885KIT 1/4885CYP2C19 3359/4885
US-10806737-B2 Compounds and methods for the targeted degradation of fetal liver kinase polypeptides MDM2, CRBN, FLT3 CSF1R 806/4885KIT 557/4885CYP2C19 4600/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.