Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XIAP | P98170 | 12/20 | 0.42 |
| ▸ | BIRC2 | Q13490 | 6/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 2/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15705294 | 0.94 | XIAP (0.40) | XIAPBIRC2HRH3DPP4 | |
| SCHEMBL16137996 | 0.87 | BIRC2 (0.54) | XIAPBIRC2DPP4DPP8DPP9 | |
| SCHEMBL9965794 | 0.82 | DPP4 (0.49) | XIAPBIRC2DPP4DPP8DPP9 | |
| SCHEMBL12674996 | 0.76 | BIRC2 (0.54) | XIAPBIRC2 | |
| SCHEMBL14535059 | 0.76 | XIAP (0.49) | XIAPBIRC2HRH3DPP4 | |
| SCHEMBL12380915 | 0.76 | XIAP (0.52) | XIAPBIRC2 | |
| SCHEMBL13073763 | 0.75 | XIAP (0.38) | XIAPBIRC2DPP4 | |
| SCHEMBL10081350 | 0.74 | BIRC2 (0.56) | XIAPBIRC2 | |
| SCHEMBL12130787 | 0.74 | BIRC2 (0.56) | XIAPBIRC2 | |
| SCHEMBL13690351 | 0.74 | BIRC2 (0.56) | XIAPBIRC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2784076-A1 | Dimeric SMAC mimetics | Joyant Pharmaceuticals, Inc. (US) | 2014-10-01 | — | — | EP | disclosed |
| WO-2011059763-A2 | DIMERIC SMAC MIMETICS | JOYANT PHARMACEUTICALS, INC. (US) | 2011-05-19 | — | — | WO | disclosed |