Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 7/20 | 0.74 |
| ▸ | HTT | P42858 | 4/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.60 |
| ▸ | MEN1 | O00255 | 5/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | SMO | Q99835 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | CKS1B | P61024 | 1/20 | 0.52 |
| ▸ | SKP1 | P63208 | 1/20 | 0.52 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1267418 | 0.89 | NPSR1 (0.59) | NPSR1HTTALDH1A1KMT2AMEN1 | |
| SCHEMBL1268380 | 0.84 | NPSR1 (0.68) | NPSR1HTTALDH1A1KMT2AMEN1 | |
| SCHEMBL1267013 | 0.81 | NPSR1 (0.72) | NPSR1HTTALDH1A1KMT2AMEN1 | |
| SCHEMBL23248771 | 0.78 | SSTR2 (0.51) | NPSR1HTTALDH1A1LMNACKS1B | |
| SCHEMBL13181182 | 0.78 | KMT2A (0.66) | NPSR1HTTALDH1A1KMT2AMEN1 | |
| SCHEMBL2278171 | 0.78 | ALDH1A1 (0.68) | NPSR1HTTALDH1A1KMT2AMEN1 | |
| SCHEMBL16269513 | 0.78 | ALDH1A1 (0.59) | NPSR1HTTALDH1A1KMT2AMEN1 | |
| SCHEMBL3779932 | 0.77 | SMO (0.54) | NPSR1HTTKMT2AMEN1MAPT | |
| Isophthalic Acid SCHEMBL28790907 | 0.77 | SMO (0.57) | NPSR1HTTKMT2AMEN1MAPT | |
| SCHEMBL12435127 | 0.75 | SMO (0.61) | NPSR1HTTALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102066353-B | Disubstituted phthalazine Hedgehog pathway antagonists | LILLY CO ELI | 2013-12-11 | — | — | CN | disclosed |
| US-7981892-B2 | Disubstituted phthalazine hedgehog pathway antagonists | ELI LILLY AND COMPANY (US) | 2011-07-19 | — | — | US | disclosed |
| CN-102066353-A | Disubstituted phthalazine Hedgehog pathway antagonists | LILLY CO ELI | 2011-05-18 | — | — | CN | disclosed |
| US-20110046143-A1 | DISUBSTITUTED PHTHALAZINE HEDGEHOG PATHWAY ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2011-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046143-A1 | DISUBSTITUTED PHTHALAZINE HEDGEHOG PATHWAY ANTAGONISTS | SHH, GLI1, SMO | NPSR1 1903/4885HTT 1781/4885ALDH1A1 2679/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.