SCHEMBL12677264

SCHEMBL12677264

Cn1ccc(O)nc1=O

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL439647 0.74
SCHEMBL27952255 0.73 PIK3CB (0.41)
SCHEMBL11250319 0.73
SCHEMBL25428969 0.73
SCHEMBL20611026 0.73
SCHEMBL23128404 0.73
SCHEMBL31227892 0.73
SCHEMBL15032488 0.72 KDM5A (0.35)
SCHEMBL12884843 0.72 KDM4E (0.34)
Iodide SCHEMBL29172953 0.71 PIK3CB (0.40)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230037255-A1 NOVEL SULFONAMIDE CARBOXAMIDE COMPOUNDS INFLAZOME LTD (IE) 2023-02-02 US disclosed
US-20220389031-A1 MACROCYCLIC SULFONYLAMIDE DERIVATIVES USEFUL AS NLRP3 INHIBITORS INFLAZOME LIMITED (IE) 2022-12-08 US disclosed
US-11370776-B2 Sulfonylureas and sulfonylthioureas as NLRP3 inhibitors INFLAZOME LIMITED (IE) 2022-06-28 US disclosed
EP-3912984-A1 4'-FLUORO-NUCLEOSIDES, 4'-FLUORO-NUCLEOTIDES AND ANALOGS THEREOF FOR THE TREATMENT OF HCV Janssen BioPharma, Inc. (US) 2021-11-24 EP disclosed
US-20210332020-A1 PHENYLSULFONYLUREA DERIVATIVES USEFUL AS NLRP3 INHIBITORS INFLAZOME LIMITED (IE) 2021-10-28 US disclosed
WO-2021043966-A1 NLRP3 INHIBITORS INFLAZOME LIMITED (IE) 2021-03-11 WO disclosed
WO-2021032591-A1 MACROCYCLIC SULFONYLUREA DERIVATIVES USEFUL AS NLRP3 INHIBITORS INFLAZOME LIMITED (IE) 2021-02-25 WO disclosed
WO-2021032588-A1 MACROCYCLIC SULFONYLAMIDE DERIVATIVES USEFUL AS NLRP3 INHIBITORS INFLAZOME LIMITED (IE) 2021-02-25 WO disclosed
US-20200270227-A1 SULFONYLUREAS AND SULFONYLTHIOUREAS AS NLRP3 INHIBITORS INFLAZOME LIMITED (IE) 2020-08-27 US disclosed
EP-2697241-B1 1'-SUBSTITUTED PYRIMIDINE N-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT GILEAD SCIENCES INC (US) 2019-06-12 EP disclosed
WO-2019008025-A1 NOVEL SULFONAMIDE CARBOXAMIDE COMPOUNDS INFLAZOME LIMITED (IE) 2019-01-10 WO disclosed
WO-2019008029-A1 SULFONYLUREAS AND SULFONYLTHIOUREAS AS NLRP3 INHIBITORS INFLAZOME LIMITED (IE) 2019-01-10 WO disclosed
EP-3421482-A1 SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF Alios Biopharma, Inc. (US) 2019-01-02 EP disclosed
US-8877733-B2 1′-substituted pyrimidine N-nucleoside analogs for antiviral treatment GILEAD SCIENCES, INC. (US) 2014-11-04 US disclosed
US-20130149283-A1 METHODS AND COMPOSITIONS FOR TREATING HEPATITIS C VIRUS UNIVERSITA DEGLI STUDI DI CAGLIARI (IT) 2013-06-13 US disclosed
US-20110111393-A1 PNA Probes, Mixtures, Methods And Kits Pertaining To The Determination Of Mycoplasma and related Mollicutes HYLDIG-NIELSEN JENS J 2011-05-12 US disclosed
US-7910563-B2 Antisense oligonucleotide to inhibit melanoma inhibitory activity, MIA ANTISENSE PHARMA GMBH (DE) 2011-03-22 US disclosed
EP-1501812-B1 PNA MONOMER AND PRECURSOR PANAGENE INC (KR) 2009-12-30 EP disclosed
EP-1012267-B1 AN ANTISENSE OLIGONUCLEOTIDE PREPARATION METHOD BIOGNOSTIK GES (DE) 2009-04-15 EP disclosed
EP-1889911-A2 An antisense oligonucleotide preparation method Biognostik Gesellschaft für biomolekulare Diagnostik mbH (DE) 2008-02-20 EP disclosed