Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 9/20 | 0.33 |
| ▸ | HTR2C | P28335 | 9/20 | 0.33 |
| ▸ | HTR2B | P41595 | 9/20 | 0.33 |
| ▸ | HTR7 | P34969 | 4/20 | 0.32 |
| ▸ | DRD2 | P14416 | 3/20 | 0.32 |
| ▸ | HTR1A | P08908 | 3/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.31 |
| ▸ | HTR6 | P50406 | 3/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.31 |
| ▸ | DRD4 | P21917 | 2/20 | 0.31 |
| ▸ | HRH2 | P25021 | 2/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1094880 | 0.85 | HTR2C (0.48) | PDE4APDE4BPDE4CPDE4DHTR2A | |
| SCHEMBL13679042 | 0.81 | HTR2C (0.52) | HTR2AHTR2CHTR2B | |
| SCHEMBL13672965 | 0.80 | HTR2A (0.43) | HTR2AHTR2CHTR2B | |
| SCHEMBL13679034 | 0.71 | HTR2C (0.53) | HTR2AHTR2CHTR2BHTR7DRD2 | |
| SCHEMBL1095198 | 0.67 | HTR2C (0.63) | HTR2AHTR2CHTR2B | |
| SCHEMBL1095335 | 0.67 | HTR2C (0.73) | HTR2AHTR2CHTR2B | |
| SCHEMBL1095337 | 0.67 | HTR2C (0.73) | HTR2AHTR2CHTR2B | |
| SCHEMBL1095359 | 0.67 | HTR2C (0.66) | HTR2AHTR2CHTR2BADRA2AADRA2B | |
| SCHEMBL1096662 | 0.67 | HTR2A (0.66) | HTR2AHTR2CHTR2BHTR1AADRA2A | |
| SCHEMBL1096664 | 0.67 | HTR2A (0.66) | HTR2AHTR2CHTR2BHTR1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2322162-A1 | 5HT2C receptor modulator compositions and methods of use | Arena Pharmaceuticals, Inc. (US) | 2011-05-18 | — | — | EP | disclosed |
| EP-2111859-A1 | 5HT2C receptor modulator compositions and methods of use | Arena Pharmaceuticals, Inc. (US) | 2009-10-28 | — | — | EP | disclosed |
| EP-1833473-B1 | 5HT2C RECEPTOR MODULATOR COMPOSITIONS AND METHODS OF USE | ARENA PHARM INC (US) | 2009-09-09 | — | — | EP | disclosed |