Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA3 | P07451 | 1/20 | 0.48 |
| ▸ | CA4 | P22748 | 1/20 | 0.48 |
| ▸ | CA6 | P23280 | 1/20 | 0.48 |
| ▸ | CA5A | P35218 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.48 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19866030 | 0.79 | LMNA (0.45) | LMNACA12CA1CA2CA3 | |
| SCHEMBL12679149 | 0.76 | LMNA (0.36) | LMNACA12CA1CA2CA3 | |
| SCHEMBL12679146 | 0.76 | LMNA (0.36) | LMNACA12CA1CA2CA3 | |
| SCHEMBL28555019 | 0.73 | LMNA (0.58) | LMNACA12CA1CA2CA3 | |
| SCHEMBL12136491 | 0.73 | LMNA (0.39) | LMNACA12CA1CA2CA3 | |
| SCHEMBL319336 | 0.72 | LMNA (0.51) | LMNACA12CA1CA2CA3 | |
| SCHEMBL6962028 | 0.72 | LMNA (0.51) | LMNACA12CA1CA2CA3 | |
| SCHEMBL7418428 | 0.72 | LMNA (0.51) | LMNACA12CA1CA2CA3 | |
| SCHEMBL14446063 | 0.72 | LMNA (0.41) | LMNACA12CA1CA2CA3 | |
| SCHEMBL20124938 | 0.71 | LMNA (0.50) | LMNACA12CA1CA2CA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8273802-B2 | Silicones formed from an oxygen permeable component and a vinyl carbonate, carbamate ester or amide beta-substituted vinyl pyrrolidone; improve wettability of the lens without a surface treatment | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2012-09-25 | — | — | US | disclosed |
| US-20080275156-A1 | WETTABLE HYDROGELS COMPRISING REACTIVE, HYDROPHILIC, POLYMERIC INTERNAL WETTING AGENTS | JOHNSON & JOHNSON VISION CARE, INC. | 2008-11-06 | — | — | US | disclosed |
| US-7249848-B2 | Wettable hydrogels comprising reactive, hydrophilic, polymeric internal wetting agents | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2007-07-31 | — | — | US | disclosed |