SCHEMBL12680403

SCHEMBL12680403

Cc1cc(N(Cc2ccccc2)Cc2ccccc2)ccc1C(C)c1ccc(C(C)c2ccc(N(Cc3ccccc3)Cc3ccccc3)cc2C)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 1/20 0.50
CRHBP P24387 1/20 0.41
CRHR2 Q13324 1/20 0.41
CNR2 P34972 3/20 0.41
TSHR P16473 1/20 0.40
MCL1 Q07820 2/20 0.39
GAA P10253 1/20 0.39
MAPT P10636 1/20 0.39
PKM P14618 1/20 0.39
HTT P42858 1/20 0.39
NR1H2 P55055 2/20 0.39
NR1H3 Q13133 2/20 0.39
S1PR1 P21453 2/20 0.39
NR3C1 P04150 1/20 0.39
CNR1 P21554 1/20 0.37
TYR P14679 1/20 0.36
CYP1A2 P05177 1/20 0.36
MAPK1 P28482 1/20 0.36
QPCT Q16769 1/20 0.36
GRM2 Q14416 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10779688 0.92 CYP2C19 (0.54) CYP2C19CRHBPCRHR2CNR2TSHR
SCHEMBL14074805 0.89 CYP2C19 (0.40) CYP2C19CRHBPCRHR2CNR2TSHR
SCHEMBL11520299 0.87 CYP2C19 (0.51) CYP2C19CRHBPCRHR2CNR2TSHR
SCHEMBL9780437 0.84 CYP2C19 (0.51) CYP2C19CRHBPCRHR2CNR2TSHR
SCHEMBL10778608 0.84 CYP2C19 (0.51) CYP2C19CRHBPCRHR2CNR2TSHR
SCHEMBL10781440 0.82 CYP2C19 (0.53) CYP2C19CRHBPCRHR2CNR2TSHR
SCHEMBL12342178 0.82 MAPT (0.54) CYP2C19CRHBPCRHR2TSHRMCL1
SCHEMBL10779746 0.81 CYP2C19 (0.63) CYP2C19CRHBPCRHR2CNR2TSHR
SCHEMBL5949383 0.81 CYP2C19 (0.63) CYP2C19CRHBPCRHR2CNR2TSHR
SCHEMBL10775313 0.81 CYP2C19 (0.51) CYP2C19CRHBPCRHR2CNR2TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8273513-B2 Image forming apparatus, process cartridge, and image bearing member RICOH COMPANY, LIMITED (JP) 2012-09-25 US disclosed
US-20100330475-A1 IMAGE FORMING APPARATUS, PROCESS CARTRIDGE, AND IMAGE BEARING MEMBER RICOH COMPANY LIMITED (JP) 2010-12-30 US disclosed
US-20090180788-A1 Image forming apparatus, and image forming method RICOH COMPANY, LTD. (JP) 2009-07-16 US disclosed
US-20080227007-A1 Image forming apparatus and process cartridge RICOH COMPANY, LTD. 2008-09-18 US disclosed