Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 9/20 | 0.57 |
| ▸ | PIK3R1 | P27986 | 8/20 | 0.57 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.57 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.57 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.57 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 6/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2507360 | 0.90 | PIK3CD (0.57) | PIK3CDPIK3R1PIK3CGPIK3CBPIK3CA | |
| SCHEMBL11901233 | 0.90 | PIK3CD (0.57) | PIK3CDPIK3R1PIK3CGPIK3CBPIK3CA | |
| Hydrochloric Acid SCHEMBL12473096 | 0.88 | PIK3CD (0.56) | PIK3CDPIK3R1PIK3CGPIK3CBPIK3CA | |
| SCHEMBL11900554 | 0.84 | PIK3CD (0.52) | PIK3CDPIK3R1PIK3CGPIK3CBPIK3CA | |
| SCHEMBL12472541 | 0.84 | PIK3CD (0.52) | PIK3CDPIK3R1PIK3CGPIK3CBPIK3CA | |
| SCHEMBL12683258 | 0.83 | PDE10A (0.52) | PIK3CDPIK3R1PIK3CGPIK3CBPIK3CA | |
| SCHEMBL2506849 | 0.82 | PIK3CD (0.56) | PIK3CDPIK3R1PIK3CGPIK3CBPIK3CA | |
| SCHEMBL12197095 | 0.80 | PIK3CD (0.48) | PIK3CDPIK3R1PIK3CGPIK3CBPIK3CA | |
| SCHEMBL2505594 | 0.79 | PIK3CD (0.48) | PIK3CDPIK3R1PIK3CGPIK3CBPIK3CA | |
| SCHEMBL2502105 | 0.79 | PIK3CD (0.48) | PIK3CDPIK3R1PIK3CGPIK3CBPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012107465-A1 | HETEROCYCLIC COMPOUNDS AS PI3 KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-08-16 | — | — | WO | disclosed |