Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.45 |
| ▸ | PIK3R1 | P27986 | 7/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | GSR | P00390 | 1/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11901355 | 0.89 | PIK3CD (0.46) | PDE10APIK3CDPIK3R1PIK3CBPIK3CG | |
| SCHEMBL12683083 | 0.83 | PIK3CD (0.57) | PDE10APIK3CDPIK3R1PIK3CBPIK3CG | |
| SCHEMBL11901816 | 0.78 | PIK3CD (0.54) | PIK3CDPIK3R1PIK3CBPIK3CGPIK3CA | |
| SCHEMBL2503207 | 0.78 | PIK3CD (0.54) | PIK3CDPIK3R1PIK3CBPIK3CGPIK3CA | |
| SCHEMBL11901385 | 0.77 | PIK3CD (0.42) | PDE10APIK3CDPIK3R1PIK3CBPIK3CG | |
| SCHEMBL12473152 | 0.76 | PIK3CD (0.55) | PDE10APIK3CDPIK3R1PIK3CBPIK3CG | |
| SCHEMBL2505813 | 0.76 | PIK3CD (0.55) | PDE10APIK3CDPIK3R1PIK3CBPIK3CG | |
| Hydrochloric Acid SCHEMBL11901325 | 0.75 | PIK3CD (0.54) | PDE10APIK3CDPIK3R1PIK3CBPIK3CG | |
| Hydrochloric Acid SCHEMBL12473126 | 0.75 | PIK3CD (0.54) | PDE10APIK3CDPIK3R1PIK3CBPIK3CG | |
| SCHEMBL2509454 | 0.74 | PIK3CD (0.54) | PIK3CDPIK3R1PIK3CBPIK3CGPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012107465-A1 | HETEROCYCLIC COMPOUNDS AS PI3 KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-08-16 | — | — | WO | disclosed |