Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | DAO | P14920 | 2/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.37 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.37 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.37 |
| ▸ | ALB | P02768 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | RARB | P10826 | 1/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3176446 | 0.84 | PDE3B (0.38) | POLBMAPTDAOLMNATSHR | |
| SCHEMBL3173218 | 0.84 | DAO (0.34) | MAPTDAOTSHRPMP22ALDH1A1 | |
| SCHEMBL2292345 | 0.83 | DAO (0.45) | MEN1KMT2ADAOLMNATSHR | |
| SCHEMBL9111655 | 0.83 | TSHR (0.39) | MEN1KMT2ADAOLMNATSHR | |
| SCHEMBL2257545 | 0.82 | MEN1 (0.44) | MEN1POLBMAPTKMT2ADAO | |
| SCHEMBL9592875 | 0.77 | PDE10A (0.47) | DAONFKB1HTR2A | |
| SCHEMBL4176572 | 0.73 | ALDH1A1 (0.41) | DAOLMNATSHRALDH1A1 | |
| SCHEMBL4169393 | 0.70 | PPARG (0.43) | MEN1POLBKMT2ACYP2C9ALDH1A1 | |
| SCHEMBL8120565 | 0.70 | PTGS1 (0.50) | MEN1POLBMAPTKMT2APTGS1 | |
| SCHEMBL2253443 | 0.69 | DAO (0.41) | MEN1KMT2ADAOALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7888487-B2 | Pyrazole derivative, medicinal composition containing the same, medicinal use thereof and intermediate in producing the same | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2011-02-15 | — | — | US | disclosed |
| US-20100029919-A1 | PYRAZOLE DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, MEDICINAL USE THEREOF AND INTERMEDIATE IN PRODUCING THE SAME | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2010-02-04 | — | — | US | disclosed |
| US-7576063-B2 | Pyrazole derivative, medicinal composition containing the same, medicinal use thereof and intermediate in producing the same | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2009-08-18 | — | — | US | disclosed |
| US-20060128635-A1 | Pyrazole derivative, medicinal composition containing the same, medicinal use thereof and intermediate in producing the same | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2006-06-15 | — | — | US | disclosed |
| EP-1550668-A1 | PYRAZOLE DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, MEDICINAL USE THEREOF AND INTERMEDIATE IN PRODUCING THE SAME | Kissei Pharmaceutical Co., Ltd. (JP) | 2005-07-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029919-A1 | PYRAZOLE DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, MEDICINAL USE THEREOF AND INTERMEDIATE IN PRODUCING THE SAME | SLC2A3, SLC2A1, SLC5A1 | MEN1 1742/4885POLB 4484/4885MAPT 1962/4885 |
| US-20060128635-A1 | Pyrazole derivative, medicinal composition containing the same, medicinal use thereof and intermediate in producing the same | SLC2A3, SLC2A1, SLC5A1 | MEN1 1948/4885POLB 4467/4885MAPT 1707/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.