Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1269683 | 0.92 | KMT2A (0.52) | ALDH1A1KMT2AHPGDHTTSMN1; SMN2 | |
| SCHEMBL1269618 | 0.90 | KMT2A (0.47) | KMT2AHTTSMN1; SMN2CYP3A4CYP2C19 | |
| SCHEMBL1268378 | 0.89 | NPC1 (0.47) | ALDH1A1KMT2AHTTSMN1; SMN2MAPT | |
| SCHEMBL1269259 | 0.88 | KMT2A (0.51) | ALDH1A1KMT2AHPGDSMN1; SMN2POLB | |
| SCHEMBL12898201 | 0.87 | ROCK2 (0.47) | ALDH1A1KMT2ASMN1; SMN2POLBMAPT | |
| SCHEMBL1268398 | 0.86 | CACNA1B (0.44) | ALDH1A1KMT2AHTTSMN1; SMN2POLB | |
| SCHEMBL1268340 | 0.84 | KMT2A (0.46) | KMT2AHPGDHTTSMN1; SMN2MAPT | |
| SCHEMBL12898196 | 0.84 | GSK3B (0.49) | ALDH1A1KMT2AHPGDSMN1; SMN2POLB | |
| SCHEMBL1269553 | 0.81 | SMN1; SMN2 (0.50) | ALDH1A1KMT2AHPGDHTTSMN1; SMN2 | |
| SCHEMBL1269384 | 0.81 | NPC1 (0.43) | KMT2AHTTSMN1; SMN2MAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110039893-A1 | GSK-3BETA INHIBITOR | TAKEDA PHARMACEUTICAL COMPANY LIMITED | 2011-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110039893-A1 | GSK-3BETA INHIBITOR | GSK3B, GSK3A, GSKIP | ALDH1A1 1585/4885KMT2A 575/4885HPGD 1329/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.