Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 12/20 | 0.72 |
| ▸ | EGFR | P00533 | 10/20 | 0.72 |
| ▸ | KDR | P35968 | 4/20 | 0.72 |
| ▸ | RAF1 | P04049 | 5/20 | 0.65 |
| ▸ | CA2 | P00918 | 1/20 | 0.60 |
| ▸ | CA9 | Q16790 | 1/20 | 0.60 |
| ▸ | KIT | P10721 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12694355 | 0.87 | KDR (0.71) | BRAFEGFRKDR | |
| SCHEMBL12694351 | 0.84 | EGFR (0.67) | BRAFEGFRKDRRAF1KIT | |
| SCHEMBL12694386 | 0.84 | EGFR (1.00) | BRAFEGFRKDRRAF1KIT | |
| SCHEMBL30664588 | 0.79 | RAF1 (1.00) | BRAFEGFRKDRRAF1 | |
| SCHEMBL21750863 | 0.79 | RAF1 (1.00) | BRAFEGFRKDRRAF1 | |
| SCHEMBL12694305 | 0.79 | KDR (1.00) | BRAFEGFRKDRKIT | |
| SCHEMBL3947811 | 0.76 | KDR (0.59) | BRAFEGFRKDRRAF1CA2 | |
| SCHEMBL3948976 | 0.76 | BRAF (0.60) | BRAFEGFRKDRRAF1CA2 | |
| SCHEMBL3944523 | 0.76 | BRAF (0.60) | BRAFEGFRKDRRAF1CA2 | |
| SCHEMBL1015580 | 0.76 | BRAF (0.88) | BRAFRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012089137-A1 | ARYLUREA COMPOUND, INTERMEDIATE AND USE THEREOF | 上海医药工业研究院 (CN) | 2012-07-05 | — | — | WO | disclosed |