Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.67 |
| ▸ | KDR | P35968 | 4/20 | 0.67 |
| ▸ | AURKA | O14965 | 2/20 | 0.66 |
| ▸ | FBP1 | P09467 | 2/20 | 0.65 |
| ▸ | FLT1 | P17948 | 2/20 | 0.64 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.64 |
| ▸ | LCK | P06239 | 2/20 | 0.63 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.63 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.61 |
| ▸ | FLT4 | P35916 | 2/20 | 0.61 |
| ▸ | FLT3 | P36888 | 2/20 | 0.61 |
| ▸ | PLK4 | O00444 | 1/20 | 0.61 |
| ▸ | CIT | O14578 | 1/20 | 0.61 |
| ▸ | GAK | O14976 | 1/20 | 0.61 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.61 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.61 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.61 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.61 |
| ▸ | BUB1 | O43683 | 1/20 | 0.61 |
| ▸ | KDM1A | O60341 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14551678 | 0.91 | FBP1 (0.77) | EGFRKDRAURKAFBP1FLT1 | |
| SCHEMBL12694355 | 0.88 | KDR (0.71) | EGFRKDRFBP1ERBB2BRAF | |
| SCHEMBL10101915 | 0.85 | EGFR (0.78) | EGFRKDRAURKAFBP1FLT1 | |
| SCHEMBL12694359 | 0.84 | BRAF (0.72) | EGFRKDRRAF1KITBRAF | |
| SCHEMBL31067733 | 0.84 | KDR (0.80) | EGFRKDRLCKPDGFRBFLT4 | |
| SCHEMBL12694370 | 0.82 | EGFR (0.85) | EGFRKDRAURKALCKAURKB | |
| SCHEMBL28415090 | 0.81 | EGFR (0.74) | EGFRKDRAURKAFBP1FLT1 | |
| SCHEMBL10106511 | 0.80 | EGFR (0.75) | EGFRKDRAURKAFBP1FLT1 | |
| SCHEMBL28404498 | 0.80 | EGFR (0.71) | EGFRKDRAURKAFBP1FLT1 | |
| SCHEMBL12694358 | 0.80 | EGFR (0.63) | EGFRKDRAURKABRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012089137-A1 | ARYLUREA COMPOUND, INTERMEDIATE AND USE THEREOF | 上海医药工业研究院 (CN) | 2012-07-05 | — | — | WO | disclosed |