Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | PNMT | P11086 | 1/20 | 0.42 |
| ▸ | PDCD1 | Q15116 | 12/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 12/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | HTR5A | P47898 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20356369 | 0.82 | CDK4 (0.41) | JAK2CDK4HTR5ALMNATP53 | |
| SCHEMBL20203452 | 0.80 | FLT3 (0.47) | FLT3JAK2PNMTPDCD1CD274 | |
| SCHEMBL22544270 | 0.79 | RAD52 (0.49) | PNMTLMNATP53MAPT | |
| SCHEMBL29591564 | 0.79 | CDK4 (0.40) | PDCD1CD274CDK4LMNATP53 | |
| SCHEMBL28625493 | 0.78 | DRD2 (0.37) | PDCD1CD274TP53MAPT | |
| Hydrochloric Acid SCHEMBL29591446 | 0.78 | CDK4 (0.40) | PDCD1CD274CDK4LMNATP53 | |
| SCHEMBL20037477 | 0.74 | PDCD1 (0.47) | FLT3JAK2PNMTPDCD1CD274 | |
| SCHEMBL18819902 | 0.74 | PDCD1 (0.52) | FLT3JAK2PDCD1CD274CDK4 | |
| SCHEMBL12101137 | 0.73 | CYP2C9 (0.47) | LMNAMAPT | |
| SCHEMBL30316371 | 0.73 | CYP2C9 (0.47) | LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012129344-A1 | FUSED TRICYCLIC DUAL INHIBITORS OF CDK 4/6 AND FLT3 | AMGEN INC. (US) | 2012-09-27 | — | — | WO | disclosed |