Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYR | P14679 | 1/20 | 0.47 |
| ▸ | RXRA | P19793 | 1/20 | 0.46 |
| ▸ | RXRB | P28702 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2726596 | 0.82 | CA12 (0.42) | RAB9AKDM4ESMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL9663328 | 0.82 | KMT2A (0.45) | TYRRXRARXRBRAB9AKMT2A | |
| SCHEMBL19043466 | 0.81 | KMT2A (0.49) | TYRRXRARXRBRAB9AKMT2A | |
| SCHEMBL14275899 | 0.80 | CYP2D6 (0.51) | RXRARXRBRAB9AKMT2AMEN1 | |
| SCHEMBL10714219 | 0.79 | MEN1 (0.51) | TYRRXRARXRBRAB9AKMT2A | |
| SCHEMBL5255909 | 0.78 | MEN1 (0.50) | TYRRXRARXRBRAB9AKMT2A | |
| SCHEMBL10714708 | 0.78 | KMT2A (0.42) | TYRRXRARXRBRAB9AKMT2A | |
| SCHEMBL20442679 | 0.77 | NQO1 (0.64) | RAB9AKMT2AMEN1NPC1KDM4E | |
| SCHEMBL230017 | 0.77 | DRD2 (0.48) | KDM4EL3MBTL1 | |
| SCHEMBL794717 | 0.77 | DRD4 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2594626-B1 | Use of oxyacetaldehyde as lily of the valley fragrance | SYMRISE AG (DE) | 2014-06-25 | — | — | EP | claimed |
| EP-2594626-A1 | Use of oxyacetaldehyde as lily of the valley fragrance | Symrise AG (DE) | 2013-05-22 | — | — | EP | claimed |
| EP-2968347-B1 | MODULATORS OF THE EIF2ALPHA PATHWAY | UNIV CALIFORNIA (US) | 2023-08-02 | — | — | EP | disclosed |
| US-20210139458-A1 | TETRAHYDRONAPHTHALENE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | ARVINAS OPERATIONS, INC. | 2021-05-13 | — | — | US | disclosed |
| US-10647698-B2 | Tetrahydronaphthalene and tetrahydroisoquinoline derivatives as estrogen receptor degraders | ARVINAS OPERATIONS, INC. (US) | 2020-05-12 | — | — | US | disclosed |
| EP-2594563-B1 | 2-acylaminopropanol-type glucosylceramide synthase inhibitors | GENZYME CORP (US) | 2018-07-18 | — | — | EP | disclosed |
| US-20180155322-A1 | TETRAHYDRONAPHTHALENE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | ARVINAS OPERATIONS, INC. | 2018-06-07 | — | — | US | disclosed |
| US-9744153-B2 | 2-acylaminopropoanol-type glucosylceramide synthase inhibitors | GENZYME CORPORATION (US) | 2017-08-29 | — | — | US | disclosed |
| US-9745294-B2 | 2-acylaminopropoanol-type glucosylceramide synthase inhibitors | GENZYME CORPORATION (US) | 2017-08-29 | — | — | US | disclosed |
| EP-2320886-B1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITION FOR THE TREATMENT OF COLLAPSING GLOMERULOPATHY AND OTHER GLOMERULAR DISEASE | GENZYME CORP (US) | 2017-06-28 | — | — | EP | disclosed |
| US-8871976-B2 | Chalcone structure fluorescence dye for embryonic stem cell probe | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2014-10-28 | — | — | US | disclosed |
| EP-2594626-B1 | Use of oxyacetaldehyde as lily of the valley fragrance | SYMRISE AG (DE) | 2014-06-25 | — | — | EP | disclosed |
| EP-2594626-B1 | Use of oxyacetaldehyde as lily of the valley fragrance | SYMRISE AG (DE) | 2014-06-25 | — | — | EP | disclosed |
| US-20130224790-A1 | Chalcone Structure Fluorescence Dye For Embryonic Stem Cell Probe | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2013-08-29 | — | — | US | disclosed |
| EP-2594626-A1 | Use of oxyacetaldehyde as lily of the valley fragrance | Symrise AG (DE) | 2013-05-22 | — | — | EP | disclosed |
| EP-2594626-A1 | Use of oxyacetaldehyde as lily of the valley fragrance | Symrise AG (DE) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012129564-A2 | PROTEASOME CHYMOTRYPSIN-LIKE INHIBITION USING PI-1833 ANALOGS | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2012-09-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210139458-A1 | TETRAHYDRONAPHTHALENE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | MDM2, CRBN, VHL | TYR 4421/4885RXRA 1430/4885RXRB 1265/4885 |
| US-20180155322-A1 | TETRAHYDRONAPHTHALENE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | MDM2, CRBN, VHL | TYR 4421/4885RXRA 1430/4885RXRB 1265/4885 |
| US-10647698-B2 | Tetrahydronaphthalene and tetrahydroisoquinoline derivatives as estrogen receptor degraders | MDM2, CRBN, VHL | TYR 4421/4885RXRA 1430/4885RXRB 1265/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.