Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 4/20 | 0.54 |
| ▸ | CA1 | P00915 | 4/20 | 0.54 |
| ▸ | CA2 | P00918 | 4/20 | 0.54 |
| ▸ | CA7 | P43166 | 4/20 | 0.54 |
| ▸ | CA9 | Q16790 | 4/20 | 0.54 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.54 |
| ▸ | MGLL | Q99685 | 1/20 | 0.45 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CCNC | P24863 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PAK1 | Q13153 | 4/20 | 0.40 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20261717 | 0.82 | CA12 (0.73) | CA12CA1CA2CA7CA9 | |
| SCHEMBL3310693 | 0.80 | HPGD (0.52) | RIPK1ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL21259942 | 0.80 | PROKR1 (0.47) | RIPK1ALDH1A1HPGDMEN1LMNA | |
| SCHEMBL13751474 | 0.80 | POLB (0.50) | RIPK1HPGDMEN1KMT2A | |
| SCHEMBL17276467 | 0.79 | HPGD (0.55) | CA12CA1CA2CA7CA9 | |
| SCHEMBL28471523 | 0.78 | RIPK1 (0.45) | RIPK1ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL1178863 | 0.76 | SMN1; SMN2 (0.53) | RIPK1ALDH1A1HPGDKMT2ASMN1; SMN2 | |
| SCHEMBL13741680 | 0.76 | HRH3 (0.50) | — | |
| SCHEMBL18753791 | 0.75 | CA12 (0.65) | CA12CA1CA2CA7CA9 | |
| SCHEMBL1512436 | 0.75 | CA12 (0.65) | CA12CA1CA2CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012151452-A1 | PYRUVATE KINASE ACTIVATORS FOR USE IN THERAPY | AGIOS PHARMACEUTICALS, INC (US) | 2012-11-08 | — | — | WO | disclosed |
| WO-2012092442-A1 | THERAPEUTIC COMPOUNDS AND COMPOSITIONS | AGIOS PHARMACEUTICALS, INC. (US) | 2012-07-05 | — | — | WO | disclosed |