Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 13/20 | 0.50 |
| ▸ | FYN | P06241 | 4/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.47 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.47 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | IKBKB | O14920 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12699555 | 0.89 | FYN (0.63) | PIM1FYNKCNH2SYKIKBKB | |
| SCHEMBL12699340 | 0.86 | FYN (0.52) | PIM1FYNKCNH2SYK | |
| SCHEMBL12350891 | 0.86 | FYN (0.52) | PIM1FYNKCNH2SYK | |
| SCHEMBL3039012 | 0.83 | MKNK1 (0.63) | PIM1FYNKCNH2SYK | |
| SCHEMBL2356723 | 0.83 | PIM1 (0.49) | PIM1FYNKCNH2SYK | |
| SCHEMBL2941615 | 0.82 | FYN (0.51) | PIM1FYNPIM3PIM2SYK | |
| SCHEMBL2237814 | 0.81 | PIM1 (0.47) | PIM1FYNKCNH2SYK | |
| SCHEMBL12699568 | 0.81 | USP30 (0.49) | PIM1FYNKCNH2 | |
| SCHEMBL26915253 | 0.81 | PIM1 (0.65) | PIM1KCNH2PIM3PIM2SYK | |
| SCHEMBL2240581 | 0.80 | KCNH2 (0.51) | PIM1FYNKCNH2SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012127212-A1 | IMIDAZO [1, 2 - B] PYRIDAZINE DERIVATIVES AS CDPK1 INHIBITORS | MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) | 2012-09-27 | — | — | WO | disclosed |