Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 10/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.48 |
| ▸ | FYN | P06241 | 3/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12351112 | 0.91 | PIM1 (0.47) | PIM1KCNH2FYNMKNK1 | |
| SCHEMBL12699340 | 0.89 | FYN (0.52) | PIM1KCNH2FYNSYKMAPT | |
| SCHEMBL12699555 | 0.88 | FYN (0.63) | PIM1KCNH2FYNSYKMAPT | |
| SCHEMBL12350891 | 0.87 | FYN (0.52) | PIM1KCNH2FYNSYKMAPT | |
| SCHEMBL12351067 | 0.87 | PIM1 (0.53) | PIM1KCNH2FYNMKNK1 | |
| SCHEMBL2358340 | 0.87 | PIM1 (0.53) | PIM1KCNH2FYNMKNK1 | |
| SCHEMBL3039012 | 0.86 | MKNK1 (0.63) | PIM1KCNH2FYNSYKMAPT | |
| SCHEMBL2237814 | 0.86 | PIM1 (0.47) | PIM1KCNH2FYNSYKMAPT | |
| SCHEMBL2240581 | 0.85 | KCNH2 (0.51) | PIM1KCNH2FYNSYKMAPT | |
| SCHEMBL12699587 | 0.83 | PIM1 (0.50) | PIM1KCNH2FYNSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011101640-A1 | FUSED HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF MALARIA | MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) | 2011-08-25 | — | — | WO | disclosed |
| WO-2011101640-A1 | FUSED HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF MALARIA | MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) | 2011-08-25 | — | — | WO | disclosed |