Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMP | P19971 | 2/20 | 0.45 |
| ▸ | DUT | P33316 | 5/20 | 0.41 |
| ▸ | P2RY2 | P41231 | 2/20 | 0.41 |
| ▸ | P2RY4 | P51582 | 1/20 | 0.41 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | POLA1 | P09884 | 1/20 | 0.39 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.37 |
| ▸ | NT5E | P21589 | 1/20 | 0.36 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.36 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13575501 | 0.89 | P2RY2 (0.54) | TYMPDUTP2RY2P2RY4P2RY14 | |
| SCHEMBL31657584 | 0.88 | CYP3A4 (0.52) | TYMPDUTP2RY2P2RY4P2RY14 | |
| SCHEMBL31657606 | 0.88 | CYP3A4 (0.52) | TYMPDUTP2RY2P2RY4P2RY14 | |
| SCHEMBL31467672 | 0.88 | TYMP (0.45) | TYMPDUTP2RY2P2RY4P2RY14 | |
| SCHEMBL19185368 | 0.88 | CYP3A4 (0.52) | TYMPDUTP2RY2P2RY4P2RY14 | |
| SCHEMBL17737292 | 0.88 | CYP3A4 (0.52) | TYMPDUTP2RY2P2RY4P2RY14 | |
| SCHEMBL21905172 | 0.88 | TYMP (0.45) | TYMPDUTP2RY2P2RY4P2RY14 | |
| SCHEMBL13837115 | 0.88 | TYMP (0.45) | TYMPDUTP2RY2P2RY4P2RY14 | |
| SCHEMBL12701523 | 0.87 | CYP3A4 (0.39) | TYMPDUTP2RY2P2RY4P2RY14 | |
| SCHEMBL12701588 | 0.86 | TYMP (0.40) | TYMPDUTP2RY2P2RY4P2RY14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8431588-B2 | Cyclopropyl polymerase inhibitors | JANSSEN PRODUCTS, LP (US) | 2013-04-30 | — | — | US | disclosed |
| US-8431588-B2 | Cyclopropyl polymerase inhibitors | JANSSEN PRODUCTS, LP (US) | 2013-04-30 | — | — | US | disclosed |
| US-20110092460-A1 | CYCLOPROPYL POLYMERASE INHIBITORS | CENTOCOR ORTHO BIOTECH PRODUCTS L.P. (US) | 2011-04-21 | — | — | US | disclosed |
| US-20110092460-A1 | CYCLOPROPYL POLYMERASE INHIBITORS | CENTOCOR ORTHO BIOTECH PRODUCTS L.P. (US) | 2011-04-21 | — | — | US | disclosed |
| WO-2010000459-A1 | CYCLOPROPYL POLYMERASE INHIBITORS | CENTOCOR ORTHO BIOTECH PRODUCTS L.P. (US) | 2010-01-07 | — | — | WO | disclosed |
| EP-2141172-A1 | Cyclopropyl polymerase inhibitors | Ortho Biotech Products L.P. (US) | 2010-01-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110092460-A1 | CYCLOPROPYL POLYMERASE INHIBITORS | POLR2E, POLR2H, CTR9 | TYMP 429/4885DUT 446/4885P2RY2 983/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.